Original antigenic sin in the influenza vaccination and its influence

[tetano]

Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Oct 6;53(10):1070-1074. doi: 10.3760/cma.j.issn.0253-9624.2019.10.023. [Original antigenic sin in the influenza vaccination and its influence].

[Article in Chinese; Abstract available in Chinese from the publisher]

Jiang HDC¹, Zhu FC².
Author information

1 School of Public Health, Southeast University, Nanjing 210009, China. 2 NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

Abstract

in English, Chinese
Original antigenic sin may exist in the influenza virus infection or vaccination, which possibly reduces the protective efficacy in repeated influenza vaccination. This paper reviews the literature on the original antigenic sin and its influence in influenza vaccination, and interprets the possible mechanism of this phenomenon from the three aspects of influenza virus structure, humoral immunity and cellular immunity. A large number of studies have shown that original antigen sin has a negative impact on influenza vaccination, but the evidence disproveing this phenomenon also exist, so multi-center large-scale clinical trials should be conducted to provide evidence-based basis for reaearching whether original antigen sin exists and its effects. in order to provide reference for the development and update of noval influenza vaccines and its formulation of immunization strategies.


KEYWORDS:

Influenza vaccines; Mechanism; Original antigenic sin

PMID: 31607059 DOI: 10.3760/cma.j.issn.0253-9624.2019.10.023
[Indexed for MEDLINE]