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Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects

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  • Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects

    J Infect Dis. 2019 Aug 26. pii: jiz433. doi: 10.1093/infdis/jiz433. [Epub ahead of print]
    Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects.

    Richards KA1, Shannon I2, Treanor JJ3, Yang H4, Nayak JL4, Sant AJ1.
    Author information

    1 David H. Smith Center for Vaccine Biology and Immunology Department of Microbiology and Immunology University of Rochester Medical Center Rochester, NY. 2 Department of Pediatrics, Division of Infectious Diseases University of Rochester Medical Center Rochester, NY. 3 Department of Medicine, Division of Infectious Diseases University of Rochester Medical Center Rochester, NY. 4 Department of Biostatistics and Computational Biology University of Rochester Medical Center Crittenden Blvd. Rochester, NY.

    Abstract

    Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B cell responses, CD4 T cell responses have not yet been examined. Here, we analyze CD4 T cell responses to influenza vaccination in subjects who differ in their vaccine history. We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T cell responses and diminished antibody responses. These results suggest that limiting CD4 T cell help may underlie the diminished or altered antibody responses in repeatedly vaccinated subjects.
    ? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.


    KEYWORDS:

    CD4 T cells; Influenza virus; cell-mediated immunity; influenza vaccine

    PMID: 31504634 DOI: 10.1093/infdis/jiz433

  • #2
    J Infect Dis. 2019 Aug 26. pii: jiz434. doi: 10.1093/infdis/jiz434. [Epub ahead of print]
    Repeated Seasonal Influenza Vaccination-How Much is Too Much of a Good Thing?

    Stacey HD1, Miller MS1.
    Author information

    1 Michael G. DeGroote Institute for Infectious Diseases Research, McMaster Immunology Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

    PMID: 31504654 DOI: 10.1093/infdis/jiz434

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