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Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people

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  • Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people

    Immun Ageing. 2019 Jul 5;16:14. doi: 10.1186/s12979-019-0154-y. eCollection 2019.
    Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people.

    Herrero-Fern?ndez I1, Rosado-S?nchez I1, ?lvarez-R?os AI1,2, Galv? MI3, De Luna-Romero M1, Sanbonmatsu-G?mez S4, P?rez-Ruiz M4, Navarro-Mar? JM4, Carrillo-Vico A1,5, S?nchez B6, Ramos R3, Ca?izares J3, Leal M#1,7, Pacheco YM#1,8.
    Author information

    Abstract

    Background:

    Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeostatic parameters in the elderly that could impact influenza vaccine responsiveness.
    Methods:

    Subjects (> 60 years old) who were vaccinated against influenza virus were included, and the vaccine response was measured by a haemagglutination inhibition (HAI) test. At baseline, peripheral CD4 and CD8 T-cells were phenotypically characterized. Thymic function and the levels of different inflammation-related biomarkers, including Lipopolysaccharide Binding Protein (LBP) and anti-cytomegalovirus (CMV) IgG antibodies, were also measured.
    Results:

    Influenza vaccine non-responders showed a tendency of higher frequency of regulatory T-cells (Tregs) before vaccination than responders (1.49 [1.08-1.85] vs. 1.12 [0.94-1.63], respectively, p = 0.061), as well as higher expression of the proliferation marker Ki67 in Tregs and different CD4 and CD8 T-cell maturational subsets. The levels of inflammation-related biomarkers correlated with the frequencies of different proliferating T-cell subsets and with thymic function (e.g., thymic function with D-dimers, r = - 0.442, p = 0.001).
    Conclusions:

    Age-related homeostatic dysregulation involving the proliferation of CD4 and CD8 T-cell subsets, including Tregs, was related to a limited responsiveness to influenza vaccination and a higher inflammatory status in a cohort of elderly people.


    KEYWORDS:

    Inflammation; Ki67; TREC; Thymic function; Treg

    PMID: 31312227 PMCID: PMC6612162 DOI: 10.1186/s12979-019-0154-y
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