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J Clin Microbiol. 2019 Jun 12. pii: JCM.00363-19. doi: 10.1128/JCM.00363-19. [Epub ahead of print]
Invasive pneumococcal disease and influenza activity in pediatric population. Impact of PCV13 vaccination in pandemic and non-pandemic influenza periods.
Hern?ndez S1, Mu?oz-Almagro C2,3,4,5, Ciruela P6,2, Soldevila N2,7, Izquierdo C6, Codina MG8, D?az A9, Moraga-Llop F8, Garc?a-Garc?a JJ2,3,4, Dom?nguez ?7,2; Working Group of Projects PI11/02081 and PI11/2345.
Author information
Abstract
Objectives: To analyze the incidence, clinical presentation, severity, invasive pneumococcal disease (IPD)-causing serotypes and the impact of the 13-valent pneumococcal conjugate vaccination during epidemic and non-epidemic influenza periods in Catalonia.Methods: Prospective study in persons aged <18 years diagnosed with IPD between 2012 and 2015 in three Catalan pediatric hospitals. IPD was defined as clinical infection together with isolation of S.pneumoniae by culture and/or detection by reverse transcription polymerase chain reaction in a normally-sterile sample. Incidence rate ratios (IRR) and the fraction of IPD prevented associated with 13-valent pneumococcal conjugate vaccine (PCV13) were calculated. The bivariate analysis used the X2 test and the multivariate analysis non-conditional logistic regression.Results: 229 cases of IPD were recorded. The incidence was higher during influenza epidemic periods (IRR: 2.7, 2.05-3.55, p <0.001), especially for pneumonia (IRR: 3.25, 2.36-4.47, p <0.001), with no differences in the distribution of pneumococcal serotypes. Complications during admission and sequel at discharge were greater during epidemic periods (aOR = 2.00, 1.06-3.77, p = 0.03 and aOR = 3.38, 1.37-8.29, p = 0.01). The preventable fraction for the population (PFp) of IPD in children aged 7-59 months was 48-49.4%. The PFp was higher in influenza epidemic than non-epidemic periods and increased when ≥2 doses of PCV13 or ≥1 after 24 months were administered.Conclusions: Influenza virus circulation increases the incidence of IPD in persons aged <18 years. In influenza epidemic periods, IPD cases were more severe. Increased PCV13 coverage might increase the fraction of IPD prevented in epidemic and non-epidemic periods.
Copyright ? 2019 American Society for Microbiology.
PMID: 31189583 DOI: 10.1128/JCM.00363-19
Invasive pneumococcal disease and influenza activity in pediatric population. Impact of PCV13 vaccination in pandemic and non-pandemic influenza periods.
Hern?ndez S1, Mu?oz-Almagro C2,3,4,5, Ciruela P6,2, Soldevila N2,7, Izquierdo C6, Codina MG8, D?az A9, Moraga-Llop F8, Garc?a-Garc?a JJ2,3,4, Dom?nguez ?7,2; Working Group of Projects PI11/02081 and PI11/2345.
Author information
Abstract
Objectives: To analyze the incidence, clinical presentation, severity, invasive pneumococcal disease (IPD)-causing serotypes and the impact of the 13-valent pneumococcal conjugate vaccination during epidemic and non-epidemic influenza periods in Catalonia.Methods: Prospective study in persons aged <18 years diagnosed with IPD between 2012 and 2015 in three Catalan pediatric hospitals. IPD was defined as clinical infection together with isolation of S.pneumoniae by culture and/or detection by reverse transcription polymerase chain reaction in a normally-sterile sample. Incidence rate ratios (IRR) and the fraction of IPD prevented associated with 13-valent pneumococcal conjugate vaccine (PCV13) were calculated. The bivariate analysis used the X2 test and the multivariate analysis non-conditional logistic regression.Results: 229 cases of IPD were recorded. The incidence was higher during influenza epidemic periods (IRR: 2.7, 2.05-3.55, p <0.001), especially for pneumonia (IRR: 3.25, 2.36-4.47, p <0.001), with no differences in the distribution of pneumococcal serotypes. Complications during admission and sequel at discharge were greater during epidemic periods (aOR = 2.00, 1.06-3.77, p = 0.03 and aOR = 3.38, 1.37-8.29, p = 0.01). The preventable fraction for the population (PFp) of IPD in children aged 7-59 months was 48-49.4%. The PFp was higher in influenza epidemic than non-epidemic periods and increased when ≥2 doses of PCV13 or ≥1 after 24 months were administered.Conclusions: Influenza virus circulation increases the incidence of IPD in persons aged <18 years. In influenza epidemic periods, IPD cases were more severe. Increased PCV13 coverage might increase the fraction of IPD prevented in epidemic and non-epidemic periods.
Copyright ? 2019 American Society for Microbiology.
PMID: 31189583 DOI: 10.1128/JCM.00363-19