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Contribution of vaccine-induced immunity toward either the HA or the NA component of influenza viruses limits secondary bacterial complications. (J Virol., abstract, edited)
6. J Virol. 2010 Feb 3. [Epub ahead of print]
Contribution of vaccine-induced immunity toward either the HA or the NA component of influenza viruses limits secondary bacterial complications.
Huber VC, Peltola V, McCullers JA. - Department of Infectious Disease, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN, 38105; Department of Pediatrics, Turku University Hospital, 20521 Turku, Finland.
Secondary bacterial infections contribute to morbidity and mortality from influenza. Vaccine effectiveness is typically assessed using prevention of influenza as an endpoint, not secondary infections. We vaccinated mice with formalin-inactivated influenza vaccine preparations containing disparate HA and NA proteins, and demonstrated an ability to induce the appropriate anti-HA and anti-NA immune profiles. Protection from both primary viral and secondary bacterial infection was demonstrated with vaccine-induced immunity directed toward either the HA or the NA. This finding suggests that immunity toward the NA component of the virion is desirable and should be considered in generation of influenza vaccines.
PMID: 20130054 [PubMed - as supplied by publisher]
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6. J Virol. 2010 Feb 3. [Epub ahead of print]
Contribution of vaccine-induced immunity toward either the HA or the NA component of influenza viruses limits secondary bacterial complications.
Huber VC, Peltola V, McCullers JA. - Department of Infectious Disease, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN, 38105; Department of Pediatrics, Turku University Hospital, 20521 Turku, Finland.
Secondary bacterial infections contribute to morbidity and mortality from influenza. Vaccine effectiveness is typically assessed using prevention of influenza as an endpoint, not secondary infections. We vaccinated mice with formalin-inactivated influenza vaccine preparations containing disparate HA and NA proteins, and demonstrated an ability to induce the appropriate anti-HA and anti-NA immune profiles. Protection from both primary viral and secondary bacterial infection was demonstrated with vaccine-induced immunity directed toward either the HA or the NA. This finding suggests that immunity toward the NA component of the virion is desirable and should be considered in generation of influenza vaccines.
PMID: 20130054 [PubMed - as supplied by publisher]
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