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Epistaxis and gross haematuria with severe thrombocytopaenia associated with influenza vaccination

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  • Epistaxis and gross haematuria with severe thrombocytopaenia associated with influenza vaccination

    BMJ Case Rep. 2019 May 6;12(5). pii: e229423. doi: 10.1136/bcr-2019-229423.
    Epistaxis and gross haematuria with severe thrombocytopaenia associated with influenza vaccination.

    Almohammadi A1,2, Lundin MS2,3, Abro C2,3, Hrinczenko B1,2.
    Author information

    Abstract

    Epistaxis may be attributed to many causes during the winter including dry mucous membranes from low indoor humidity from heating. However, epistaxis may also be due to thrombocytopaenia. Immune thrombocytopaenia purpura (ITP) is an autoimmune disorder causing thrombocytopaenia. Viral infections sometimes lead to ITP. Vaccines, predominantly the measles-mumps-rubella vaccine, have been associated with the development of ITP. There are several published case reports regarding influenza vaccine induced ITP. However, an association between ITP and influenza vaccination has not been firmly proven yet. We report the case of an adult with three episodes of epistaxis, each within 1 week of receiving a yearly influenza trivalent inactivated vaccine, the last episode being more severe and also featuring gross haematuria.
    BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.


    KEYWORDS:

    general practice/family medicine; haematology (incl blood transfusion); immunological products and vaccines; influenza; public health

    PMID: 31061198 DOI: 10.1136/bcr-2019-229423
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