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Cell Host Microbe. 2019 Mar 13;25(3):354-355. doi: 10.1016/j.chom.2019.02.009.
Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?
Devarajan P1, Swain SL2.
Author information
Abstract
In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.
Copyright ? 2019 Elsevier Inc. All rights reserved.
PMID: 30870620 DOI: 10.1016/j.chom.2019.02.009
Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?
Devarajan P1, Swain SL2.
Author information
Abstract
In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.
Copyright ? 2019 Elsevier Inc. All rights reserved.
PMID: 30870620 DOI: 10.1016/j.chom.2019.02.009