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Immunological responses to influenza vaccination: lessons for improving vaccine efficacy

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  • Immunological responses to influenza vaccination: lessons for improving vaccine efficacy

    Curr Opin Immunol. 2018 May 10;53:124-129. doi: 10.1016/j.coi.2018.04.026. [Epub ahead of print]
    Immunological responses to influenza vaccination: lessons for improving vaccine efficacy.

    Wang TT1, Bournazos S2, Ravetch JV3.
    Author information

    Abstract

    A critical factor in the maturation of influenza vaccine responses is the nearly inevitable binding of vaccine antigens by exiting anti-influenza IgGs. These antigen-IgG immune complexes direct the response to immunization by modulating cellular processes that determine antibody and T-cell repertoires: maturation of dendritic cells, processing and presentation of antigens to T cells, trafficking of antigens to the germinal center, and selection of B cells for antibody production. By focusing on the recent advances in the study of the immunomodulatory processes mediated by IgG immune complexes upon influenza vaccination, we discuss a pathway that is critical for modulating the breadth and potency of anti-HA antibody responses and has previously led to the development of strategies to improve influenza vaccine efficacy.


    PMID: 29753885 DOI: 10.1016/j.coi.2018.04.026
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