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BMJ Open. 2018 Mar 16;8(3):e018223. doi: 10.1136/bmjopen-2017-018223.
Effectiveness of pneumococcal and influenza vaccines to prevent serious health complications in adults with chronic liver disease: a protocol for a systematic review.
H?rm?l? S1, Parisinos C1, Shallcross L1, O'Brien A2, Hayward A3.
Author information
Abstract
INTRODUCTION:
In advanced chronic liver disease, diseases caused by common bacteria Streptococcus pneumoniae or influenza virus put people at an increased risk of serious health complications and death. The effectiveness of the available vaccines in reducing the risk of poor health outcomes, however, is less clear.
METHODS AND ANALYSIS:
We will search Medline (Ovid), Embase (Ovid), PubMed and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of pneumococcal and influenza vaccines in people with chronic liver disease. Two independent reviewers will screen the studies for eligibility, extract data and assess study quality and risk of bias. Random effects meta-analyses will be performed as appropriate.
ETHICS AND DISSEMINATION:
Formal ethical approval is not required, as no primary data will be collected for this study. We will publish results of this study in relevant peer-reviewed medical journal or journals. Where possible, the study results will also be presented as posters or talks at relevant medical conferences and meetings.
PROSPERO REGISTRATION NUMBER:
CRD42017067277.
? Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
KEYWORDS:
chronic liver disease; influenza vaccine; pneumococcal vaccine
PMID: 29549199 DOI: 10.1136/bmjopen-2017-018223
Effectiveness of pneumococcal and influenza vaccines to prevent serious health complications in adults with chronic liver disease: a protocol for a systematic review.
H?rm?l? S1, Parisinos C1, Shallcross L1, O'Brien A2, Hayward A3.
Author information
Abstract
INTRODUCTION:
In advanced chronic liver disease, diseases caused by common bacteria Streptococcus pneumoniae or influenza virus put people at an increased risk of serious health complications and death. The effectiveness of the available vaccines in reducing the risk of poor health outcomes, however, is less clear.
METHODS AND ANALYSIS:
We will search Medline (Ovid), Embase (Ovid), PubMed and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of pneumococcal and influenza vaccines in people with chronic liver disease. Two independent reviewers will screen the studies for eligibility, extract data and assess study quality and risk of bias. Random effects meta-analyses will be performed as appropriate.
ETHICS AND DISSEMINATION:
Formal ethical approval is not required, as no primary data will be collected for this study. We will publish results of this study in relevant peer-reviewed medical journal or journals. Where possible, the study results will also be presented as posters or talks at relevant medical conferences and meetings.
PROSPERO REGISTRATION NUMBER:
CRD42017067277.
? Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
KEYWORDS:
chronic liver disease; influenza vaccine; pneumococcal vaccine
PMID: 29549199 DOI: 10.1136/bmjopen-2017-018223