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No signal of interactions between influenza vaccines and drugs used for chronic diseases: a case-by-case analysis of the vaccine adverse event reporting system and vigibase

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  • No signal of interactions between influenza vaccines and drugs used for chronic diseases: a case-by-case analysis of the vaccine adverse event reporting system and vigibase

    Expert Rev Vaccines. 2018 Feb 16. doi: 10.1080/14760584.2018.1442718. [Epub ahead of print]
    No signal of interactions between influenza vaccines and drugs used for chronic diseases: a case-by-case analysis of the vaccine adverse event reporting system and vigibase.

    Carnovale C1, Raschi E2, Leonardi L2, Moretti U3, De Ponti F2, Gentili M1, Pozzi M4, Clementi E4,5, Poluzzi E2, Radice S1.
    Author information

    Abstract

    BACKGROUND:

    An increasing number of reports indicates that vaccines against influenza may interact with specific drugs via drug metabolism. To date, actual impact of vaccine-drug interactions observed in the real world clinical practice has not been investigated.
    RESEARCH DESIGN AND METHODS:

    From VAERS and VigiBase, we collected Adverse Event Following Immunization (AEFI) reports for individuals receiving vaccines against influenza recorded as suspect and selected cases where predictable toxicity was recorded with oral anticoagulants, antiepileptics and statins (i.e., hemorrhages, overdosage and rhabdomyolysis, respectively). We applied AEFI and Drug Interaction Probability Scale (DIPS) Algorithms to assess causality of drug-vaccine interactions.
    RESULTS:

    116 AEFI reports submitted to VAERS and 83 from Vigibase were included in our analysis; antiepileptics and statins were related to the highest number of indeterminate/consistent (93.7%; 65.3%) and possible/probable (50%; 57.7%) cases according to the AEFI and DIPS, respectively. The majority of cases occurred within the first week after vaccine administration (5-7 days).
    CONCLUSIONS:

    The relative paucity of detected interactions does not impact on the benefit of the vaccination against influenza, which remains strongly recommended; this does not exclude that closer monitoring for selected patients exposed to concomitant chronic pharmacological therapies and affected by predisposing factors may be useful.


    KEYWORDS:

    Adverse Event Following Immunization; antiepileptic toxicity; haemorrages; influenza vaccination; rhabdomyolysis; spontaneous reporting system database; vaccine-drug interactions

    PMID: 29452497 DOI: 10.1080/14760584.2018.1442718
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