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Enferm Infecc Microbiol Clin. 2017 Nov 24. pii: S0213-005X(17)30321-X. doi: 10.1016/j.eimc.2017.10.021. [Epub ahead of print]
Prevalence of antibodies and humoral response after seasonal trivalent vaccination against influenza B lineages in an elderly population of Spain.
[Article in English, Spanish]
Mu?oz IS1, Rello SR2, Lejarazu RO2.
Author information
Abstract
INTRODUCTION:
The aim of this study was to analyze the presence of antibodies against both Yamagata and Victoria influenza B lineages and to check the response after seasonal trivalent vaccination.
MATERIALS AND METHODS:
Haemagglutination inhibition assays were performed with pre-and post-vaccination serum samples from 174 individuals ≥65 years of age vaccinated with seasonal trivalent influenza vaccines during the 2006-2007, 2008-2009, 2009-2010 and 2010-2011 vaccine campaigns.
RESULTS:
33.9% of individuals showed pre-vaccine protective antibodies (≥1/40) against B/Yamagata lineage and 41.4% against B/Victoria lineage. The annual trivalent vaccine induced significant homologous seroconversion in 14-35.6% of individuals in each vaccine campaign.
CONCLUSIONS:
The population ≥65 years has low-moderate seroprotection against B influenza lineages. Trivalent vaccination induced a slight increase of seroprotection. The trivalent vaccine should be administered to all individuals ≥65 years in all vaccine campaigns.
Copyright ? 2017 Elsevier Espa?a, S.L.U. and Sociedad Espa?ola de Enfermedades Infecciosas y Microbiolog?a Cl?nica. All rights reserved.
KEYWORDS:
Antibodies; Anticuerpos; Influenza B lineages; Linajes de gripe B; Trivalent influenza vaccination; Vacuna trivalente de gripe
PMID: 29179984 DOI: 10.1016/j.eimc.2017.10.021
Prevalence of antibodies and humoral response after seasonal trivalent vaccination against influenza B lineages in an elderly population of Spain.
[Article in English, Spanish]
Mu?oz IS1, Rello SR2, Lejarazu RO2.
Author information
Abstract
INTRODUCTION:
The aim of this study was to analyze the presence of antibodies against both Yamagata and Victoria influenza B lineages and to check the response after seasonal trivalent vaccination.
MATERIALS AND METHODS:
Haemagglutination inhibition assays were performed with pre-and post-vaccination serum samples from 174 individuals ≥65 years of age vaccinated with seasonal trivalent influenza vaccines during the 2006-2007, 2008-2009, 2009-2010 and 2010-2011 vaccine campaigns.
RESULTS:
33.9% of individuals showed pre-vaccine protective antibodies (≥1/40) against B/Yamagata lineage and 41.4% against B/Victoria lineage. The annual trivalent vaccine induced significant homologous seroconversion in 14-35.6% of individuals in each vaccine campaign.
CONCLUSIONS:
The population ≥65 years has low-moderate seroprotection against B influenza lineages. Trivalent vaccination induced a slight increase of seroprotection. The trivalent vaccine should be administered to all individuals ≥65 years in all vaccine campaigns.
Copyright ? 2017 Elsevier Espa?a, S.L.U. and Sociedad Espa?ola de Enfermedades Infecciosas y Microbiolog?a Cl?nica. All rights reserved.
KEYWORDS:
Antibodies; Anticuerpos; Influenza B lineages; Linajes de gripe B; Trivalent influenza vaccination; Vacuna trivalente de gripe
PMID: 29179984 DOI: 10.1016/j.eimc.2017.10.021