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Euro Surveill. 2017 Jul 27;22(30). pii: 30580. doi: 10.2807/1560-7917.ES.2017.22.30.30580.
2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project.
Rondy M1, Larrauri A2,3, Casado I3,4, Alfonsi V5, Pitigoi D6, Launay O7,8, Syrj?nen RK9, Gefenaite G10, Machado A11, Vučina VV12, Horv?th JK13, Paradowska-Stankiewicz I14, Marbus SD15, Gherasim A2,3, D?az-Gonz?lez JA4, Rizzo C5, Ivanciuc AE16, Galtier F7,17, Ikonen N18, Mickiene A10, Gomez V11, Kurečić Filipović S12, Ferenczi A13, Korcinska MR14, van Gageldonk-Lafeber R15; I-MOVE+ hospital working group19, Valenciano M1.
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Abstract
We conducted a multicentre test-negative case-control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.
This article is copyright of The Authors, 2017.
KEYWORDS:
case control; elderly; hospitalisation; influenza; severe acute respiratory infection; vaccine effectiveness; vaccine-preventable diseases
PMID: 28797322 DOI: 10.2807/1560-7917.ES.2017.22.30.30580
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2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project.
Rondy M1, Larrauri A2,3, Casado I3,4, Alfonsi V5, Pitigoi D6, Launay O7,8, Syrj?nen RK9, Gefenaite G10, Machado A11, Vučina VV12, Horv?th JK13, Paradowska-Stankiewicz I14, Marbus SD15, Gherasim A2,3, D?az-Gonz?lez JA4, Rizzo C5, Ivanciuc AE16, Galtier F7,17, Ikonen N18, Mickiene A10, Gomez V11, Kurečić Filipović S12, Ferenczi A13, Korcinska MR14, van Gageldonk-Lafeber R15; I-MOVE+ hospital working group19, Valenciano M1.
Author information
Abstract
We conducted a multicentre test-negative case-control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.
This article is copyright of The Authors, 2017.
KEYWORDS:
case control; elderly; hospitalisation; influenza; severe acute respiratory infection; vaccine effectiveness; vaccine-preventable diseases
PMID: 28797322 DOI: 10.2807/1560-7917.ES.2017.22.30.30580
Free full text