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Age dependent differences in the kinetics of γδ T cells after influenza vaccination

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  • Age dependent differences in the kinetics of γδ T cells after influenza vaccination

    PLoS One. 2017 Jul 11;12(7):e0181161. doi: 10.1371/journal.pone.0181161. eCollection 2017.
    Age dependent differences in the kinetics of γδ T cells after influenza vaccination.

    Stervbo U1,2, Pohlmann D1, Baron U3, Bozzetti C1, Jürchott K1, Mälzer JN1, Nienen M2, Olek S3, Roch T4, Schulz AR1,5, Warth S1, Neumann A1, Thiel A1, Grützkau A5, Babel N1,2.
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    Abstract

    Immunosenescence is a hallmark of the aging immune system and is considered the main cause of a reduced vaccine efficacy in the elderly. Although γδ T cells can become activated by recombinant influenza hemagglutinin, their age-related immunocompetence during a virus-induced immune response has so far not been investigated. In this study we evaluate the kinetics of γδ T cells after vaccination with the trivalent 2011/2012 northern hemisphere seasonal influenza vaccine. We applied multi-parametric flow cytometry to a cohort of 21 young (19-30 years) and 23 elderly (53-67 years) healthy individuals. Activated and proliferating γδ T cells, as identified by CD38 and Ki67 expression, were quantified on the days 0, 3, 7, 10, 14, 17, and 21. We observed a significantly lower number of activated and proliferating γδ T cells at baseline and following vaccination in elderly as compared to young individuals. The kinetics changes of activated γδ T cells were much stronger in the young, while corresponding changes in the elderly occurred slower. In addition, we observed an association between day 21 HAI titers of influenza A and the frequencies of Ki67+ γδ T cells at day 7 in the young. In conclusion, aging induces alterations of the γδ T cell response that might have negative implications for vaccination efficacy.


    PMID: 28700738 DOI: 10.1371/journal.pone.0181161
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