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Hum Vaccin Immunother. 2017 May 8:0. doi: 10.1080/21645515.2017.1321722. [Epub ahead of print]
Influenza vaccine effectiveness among high-risk groups: a systematic literature review and meta-analysis of case-control and cohort studies.
Restivo V1, Costantino C1, Bono S1, Maniglia M1, Marchese V1, Ventura G1, Casuccio A1, Tramuto F1, Vitale F1.
Author information
Abstract
Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For three high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was carried out. The VE quantitative analysis demonstrated a clear significant overall effect of 39% (95%CI: 32%-46%) for visits and 57% (95%CI: 30%-74%) for hospitalization among children. Considering the elderly influenza VE had a clear effect of 25% (95%CI: 6%-40%) for visits and 14% (95%CI: 7%-21%; p<0.001) for hospitalization. This study showed the high VE of influenza vaccination among high-risk groups, representing a tool for public health decision-makers to develop evidence-based preventive interventions to avoid influenza outcomes.
KEYWORDS:
ALRI = influenza-associated acute lower respiratory infections; GP = general practitioner; HCW = Health Care Worker; ILI = influenza-like illness; Influenza; OR = Odds ratio; RR = Relative risk; SLR = systematic literature review; SOT = solid organ transplant; VE = vaccine effectiveness; WHO = World Health Organization; children; chronic disease; effectiveness; elderly subjects; health care worker; hospitalization; pregnancy; vaccine; visit
PMID: 28481673 DOI: 10.1080/21645515.2017.1321722
Influenza vaccine effectiveness among high-risk groups: a systematic literature review and meta-analysis of case-control and cohort studies.
Restivo V1, Costantino C1, Bono S1, Maniglia M1, Marchese V1, Ventura G1, Casuccio A1, Tramuto F1, Vitale F1.
Author information
Abstract
Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For three high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was carried out. The VE quantitative analysis demonstrated a clear significant overall effect of 39% (95%CI: 32%-46%) for visits and 57% (95%CI: 30%-74%) for hospitalization among children. Considering the elderly influenza VE had a clear effect of 25% (95%CI: 6%-40%) for visits and 14% (95%CI: 7%-21%; p<0.001) for hospitalization. This study showed the high VE of influenza vaccination among high-risk groups, representing a tool for public health decision-makers to develop evidence-based preventive interventions to avoid influenza outcomes.
KEYWORDS:
ALRI = influenza-associated acute lower respiratory infections; GP = general practitioner; HCW = Health Care Worker; ILI = influenza-like illness; Influenza; OR = Odds ratio; RR = Relative risk; SLR = systematic literature review; SOT = solid organ transplant; VE = vaccine effectiveness; WHO = World Health Organization; children; chronic disease; effectiveness; elderly subjects; health care worker; hospitalization; pregnancy; vaccine; visit
PMID: 28481673 DOI: 10.1080/21645515.2017.1321722