Announcement

Collapse
No announcement yet.

Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity

    Cell Immunol. 2016 Sep 7. pii: S0008-8749(16)30094-6. doi: 10.1016/j.cellimm.2016.09.005. [Epub ahead of print]
    Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity.

    Otani N1, Shima M2, Ueda T3, Ichiki K3, Nakajima K3, Takesue Y3, Okuno T4.
    Author information

    Abstract

    The immunological effect of influenza vaccines cannot be evaluated accurately using an antibody titer. Therefore, we used a new method that measures cell-mediated immunity to investigate changes in the amount of interferon-gamma (IFN-γ) produced after vaccination in response to the vaccine antigen. The study was conducted during the 2014-2015 influenza season in 23 adults, using a vaccine that contained three types of antigen. The IFN-γ level increased by at least 1.5 times in 65% (15/23) of cases in response to the H1N1 antigen, in 57% (13/23) of cases in response to the H3N2 antigen, and in 57% (13/23) of cases in response to the B antigen. During the study period, 4 subjects developed type A influenza. Our data showed that the IFN-γ level did not increase by 1.5 times in these subjects. We propose that the efficacy of influenza vaccines may be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine.
    Copyright ? 2016 Elsevier Inc. All rights reserved.


    KEYWORDS:

    Antigen; Cell-mediated immunity; Humoral immunity; Influenza; Interferon-gamma; Vaccine

    PMID: 27665371 DOI: 10.1016/j.cellimm.2016.09.005
    [PubMed - as supplied by publisher]
Working...
X