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J Virol. 2016 Jan 6. pii: JVI.03258-15. [Epub ahead of print]
A recombinant adenovirus expressing ovine interferon-tau prevents influenza virus induced lethality in mice.
Martin V1, Pascual E2, Avia M2, Rangel G2, de Molina A3, Alejo A2, Sevilla N2.
Author information
Abstract
Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and broad host range in vivo. We report the generation of a non replicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model we show that a single dose intranasal administration of the recombinant Ad5-IFN-τ can effectively prevent highly virulent hv-PR8 influenza virus induced lethality and disease by activating the interferon response and preventing viral replication.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26739058 [PubMed - as supplied by publisher]
A recombinant adenovirus expressing ovine interferon-tau prevents influenza virus induced lethality in mice.
Martin V1, Pascual E2, Avia M2, Rangel G2, de Molina A3, Alejo A2, Sevilla N2.
Author information
Abstract
Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and broad host range in vivo. We report the generation of a non replicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model we show that a single dose intranasal administration of the recombinant Ad5-IFN-τ can effectively prevent highly virulent hv-PR8 influenza virus induced lethality and disease by activating the interferon response and preventing viral replication.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26739058 [PubMed - as supplied by publisher]