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JID: Influence of Statins on Influenza Vaccine Response in Elderly Individuals

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  • JID: Influence of Statins on Influenza Vaccine Response in Elderly Individuals

    Influence of Statins on Influenza Vaccine Response in Elderly Individuals

    • 1Center for Global Health, Cincinnati Children's Hospital, Ohio
    • 2Novartis Vaccines, Marburg, Germany
    • 3Novartis Vaccines, Siena, Italy
    • Correspondence: Steven Black, MD, Center for Global Health, Cincinnati Children's Hospital, 3333 Burnett Ave, Cincinnati, OH 45229 (stevblack{at}gmail.com).



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    Abstract

    Influenza vaccination strategies have targeted elderly individuals because they are at high risk of disease complications and mortality. Statins are a class of drugs used to treat hypercholesterolemia and are frequently used in the elderly population to reduce the risk of cardiovascular disease. However, statins are also known to have immunomodulatory effects that could impact influenza vaccine response. In a post hoc analysis, we performed a cross-sectional observational study nested within a comparative immunogenicity clinical trial of adjuvanted versus unadjuvanted influenza vaccine in elderly persons to evaluate the influence of statin therapy on the immune response to vaccination. Overall, data on >5000 trial participants were available for analysis. Comparison of hemagglutination-inhibiting geometric mean titers to influenza A(H1N1), A(H3N2), and B strains revealed that titers were 38% (95% confidence interval [CI], 27%?50%), 67% (95% CI, 54%?80%), and 38% (95% CI, 28%?29%) lower, respectively, in subjects receiving chronic statin therapy, compared with those not receiving chronic statin therapy. This apparent immunosuppressive effect of statins on the vaccine immune response was most dramatic in individuals receiving synthetic statins. These effects were seen in both the adjuvanted and unadjuvanted vaccine groups in the clinical trial. These results, if confirmed, could have implications both for future clinical trials design, as well as for vaccine use recommendations for elderly individuals.




  • #2
    > statins from ??28 days before through 22 days after
    > receipt of vaccination.
    could they just stop taking statins during vaccination ?
    do statins generally impair immunity or vaccine response ?


    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

    Comment


    • #3
      The Effect of Statin Use on Influenza Vaccine Effectiveness

      • Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Foundation, Marshfield, WI 54449
      • Corresponding author: Huong McLean, PhD, MPH, Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Foundation, 1000 North Oak Ave ML2, Marshfield, WI 54449, (715) 387-3444, Fax: (715) 387-3055,Mclean.huong{at}marshfieldclinic.org

      Conclusions.Statin use was associated with reduced VE against A(H3N2), but not A(H1N1)pdm09 or type B. Further research is needed to assess biologic plausibility and confirm these results.



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