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Vaccine. 2015 Sep 30. pii: S0264-410X(15)01348-1. doi: 10.1016/j.vaccine.2015.09.072. [Epub ahead of print]
Protective antibody responses against A(H1N1)pdm09 primed by infection and recalled by intranasal vaccination.
Ikeda K1, Ainai A2, Hasegawa H3.
Author information
Abstract
This study investigated the effects of preceding infection and administration of inactivated whole virus (IWV) influenza vaccine on immune responses to a viral challenge. Preceding infection alone provided minimal reduction in virus titer following viral challenge. Single administration of intranasal or subcutaneous IWV vaccine alone failed to reduce virus titers and induce antibody responses. Subcutaneous administration of A/Narita/1/09 (A/NRT)-IWV after A/NRT infection provided complete protection against infection and yielded low nasal IgA and high serum IgG antibody responses. Subcutaneous administration of A/NRT-IWV after A/Puerto Rico/8/34 (A/PR8) infection provided no protection. Conversely, intranasal administration of A/NRT-IWV after A/NRT infection provided complete protection and high nasal IgA and serum IgG antibody responses. While, intranasal administration of A/NRT-IWV after A/PR8 infection provided moderate reduction in viral titer with moderate increases in nasal IgA antibodies. These results indicate that intranasal vaccination is superior to subcutaneous vaccination in inducing protective immune responses after preceding heterologous infection.
Copyright ? 2015. Published by Elsevier Ltd.
KEYWORDS:
Inactivated whole virus vaccine; Influenza; Intranasal vaccination
PMID: 26432916 [PubMed - as supplied by publisher]
Protective antibody responses against A(H1N1)pdm09 primed by infection and recalled by intranasal vaccination.
Ikeda K1, Ainai A2, Hasegawa H3.
Author information
Abstract
This study investigated the effects of preceding infection and administration of inactivated whole virus (IWV) influenza vaccine on immune responses to a viral challenge. Preceding infection alone provided minimal reduction in virus titer following viral challenge. Single administration of intranasal or subcutaneous IWV vaccine alone failed to reduce virus titers and induce antibody responses. Subcutaneous administration of A/Narita/1/09 (A/NRT)-IWV after A/NRT infection provided complete protection against infection and yielded low nasal IgA and high serum IgG antibody responses. Subcutaneous administration of A/NRT-IWV after A/Puerto Rico/8/34 (A/PR8) infection provided no protection. Conversely, intranasal administration of A/NRT-IWV after A/NRT infection provided complete protection and high nasal IgA and serum IgG antibody responses. While, intranasal administration of A/NRT-IWV after A/PR8 infection provided moderate reduction in viral titer with moderate increases in nasal IgA antibodies. These results indicate that intranasal vaccination is superior to subcutaneous vaccination in inducing protective immune responses after preceding heterologous infection.
Copyright ? 2015. Published by Elsevier Ltd.
KEYWORDS:
Inactivated whole virus vaccine; Influenza; Intranasal vaccination
PMID: 26432916 [PubMed - as supplied by publisher]