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Vaccine. 2009 Apr 21;27(18):2418-25. Epub 2009 Mar 3.
Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.
McElhaney JE, Ewen C, Zhou X, Kane KP, Xie D, Hager WD, Barry MB, Kleppinger A, Wang Y, Bleackley RC. - Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030, USA; Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 1L8.
This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p=0.02).
Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not.
These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults.
PMID: 19368783 [PubMed - in process]
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Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.
McElhaney JE, Ewen C, Zhou X, Kane KP, Xie D, Hager WD, Barry MB, Kleppinger A, Wang Y, Bleackley RC. - Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030, USA; Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 1L8.
This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p=0.02).
Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not.
These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults.
PMID: 19368783 [PubMed - in process]
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