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BMC Infect Dis. 2014 Nov 25;14(1):618. [Epub ahead of print]
Cost-effectiveness analysis of quadrivalent influenza vaccine versus trivalent influenza vaccine for elderly in Hong Kong.
You J, Ming WK, Chan P.
Abstract
BackgroundCost and quality-adjusted life-years (QALYs) gained by quadrivalent influenza vaccine (QIV) versus trivalent influenza vaccine (TIV) in Hong Kong elderly were estimated over 9 seasons.MethodsTIV-unmatched influenza B infection rates with QIV versus TIV were estimated by an epidemiology model. Model parameters included percentages of influenza B lineages in circulation, influenza B-associated hospital admission, age-specific population, vaccine coverage and effectiveness. Incremental cost per QALY gained (ICER) by QIV versus TIV were estimated from Hong Kong?s societal perspective.ResultsMean reduction in influenza B infection rate was 191.3 (95%CI 45.1-337.5) per 100,000 population aged ?65 years. Highest cost savings and QALYs gained by QIV occurred in 2007 with high percentage of TIV-unmatched strain (92.9%) for age groups 65?79 years (USD266,473 and 22.8 QALYs) and ?80 years (USD483,461 and 27.3 QALYs). ICERs of QIV were below willingness-to-pay for age group 65?79 years in 6, 5 and 3 years when QIV cost?+?USD1?+?USD2 and?+?USD5 more than TIV, respectively. For age group ?80 years, ICERs of QIV were below willingness-to-pay in 7 and 5 years when QIV cost?+?USD1 and?+?USD5, correspondingly.ConclusionsAcceptance of QIV to be cost-effective in Hong Kong elderly was subject to QIV unit cost and percentage of circulating TIV-unmatched influenza B lineages.
PMID:
25420713
[PubMed - as supplied by publisher]
Free full text
Cost-effectiveness analysis of quadrivalent influenza vaccine versus trivalent influenza vaccine for elderly in Hong Kong.
You J, Ming WK, Chan P.
Abstract
BackgroundCost and quality-adjusted life-years (QALYs) gained by quadrivalent influenza vaccine (QIV) versus trivalent influenza vaccine (TIV) in Hong Kong elderly were estimated over 9 seasons.MethodsTIV-unmatched influenza B infection rates with QIV versus TIV were estimated by an epidemiology model. Model parameters included percentages of influenza B lineages in circulation, influenza B-associated hospital admission, age-specific population, vaccine coverage and effectiveness. Incremental cost per QALY gained (ICER) by QIV versus TIV were estimated from Hong Kong?s societal perspective.ResultsMean reduction in influenza B infection rate was 191.3 (95%CI 45.1-337.5) per 100,000 population aged ?65 years. Highest cost savings and QALYs gained by QIV occurred in 2007 with high percentage of TIV-unmatched strain (92.9%) for age groups 65?79 years (USD266,473 and 22.8 QALYs) and ?80 years (USD483,461 and 27.3 QALYs). ICERs of QIV were below willingness-to-pay for age group 65?79 years in 6, 5 and 3 years when QIV cost?+?USD1?+?USD2 and?+?USD5 more than TIV, respectively. For age group ?80 years, ICERs of QIV were below willingness-to-pay in 7 and 5 years when QIV cost?+?USD1 and?+?USD5, correspondingly.ConclusionsAcceptance of QIV to be cost-effective in Hong Kong elderly was subject to QIV unit cost and percentage of circulating TIV-unmatched influenza B lineages.
PMID:
25420713
[PubMed - as supplied by publisher]
Free full text
