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Study: Zinc supplementation has a beneficial effect on influenza vaccination malaise in pediatric cardiac patients

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  • Study: Zinc supplementation has a beneficial effect on influenza vaccination malaise in pediatric cardiac patients

    http://www.sciencedirect.com/science...46672X11000460
    S. Songül Yalçın, Defne Engür-Karasimav, Dursun Alehan, Kadriye Yurdakök, Süheyla Özkutlu, Turgay Coşkun
    Zinc supplementation and TNF-α levels in vaccinated cardiac patients
    Journal of Trace Elements in Medicine and Biology, Volume 25, Issue 2, April 2011, Pages 85–90
    http://dx.doi.org/10.1016/j.jtemb.2011.03.002
    Abstract
    Objective

    To investigate whether zinc supplementation could affect serum tumor necrosis factor-alpha (TNF-α) levels in congenital and acquired cardiac patients attending for an influenza vaccine.
    Methods

    9–18 years old, voluntary children with cardiac disease were weighed, measured height and blood samples for hemoglobin level, zinc level, IgA and IgG titers of influenza A and B serotypes and TNF-α levels were obtained. The children were randomly assigned to 1 of 2 groups: ZV group received both zinc supplementation and influenza vaccine; V group received influenza vaccine. Serum TNF-α levels were measured at 28 days after the immunization.
    Results

    Mean (±SD) serum zinc level was 100 (±20) μg/dL. Cases with congenital heart disease had lower serum zinc levels than acquired ones (93 ± 17 μg/dL, 116 ± 18 μg/dL; respectively, p < 0.001). Median titers of serum TNF-α decreased after vaccination (78.9 pg/mL, 74.8 pg/mL; p < 0.05) but this significant change occurred only in ZV group (77.1 pg/mL, 73.4 pg/mL; p = 0.001). Vaccine associated adverse events were similar in ZV and V groups except malaise (0% in ZV and 23.8% in V group; p < 0.05). Adverse events were similar in patients with congenital and acquired heart diseases. During the previous influenza season, 77.3% had more than two episodes of upper respiratory tract infection (URTI), however, after vaccination only 13.6% had more than two episode of URTI.
    Conclusion

    Zinc supplementation has a beneficial effect on malaise, one of the influenza vaccine associated adverse events, and decrease serum TNF-α levels.

    Copyright © 2011 Elsevier GmbH. All rights reserved.
    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    Avatar: Franz Marc, Liegender Hund im Schnee 1911 (My posts are not intended as advice or professional assessments of any kind.)
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