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Vaccine. 2012 Jul 18. [Epub ahead of print]
Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study.
Puig-Barber? J, D?ez-Domingo J, Arnedo-Pena A, Ruiz-Garc?a M, P?rez-Vilar S, Mic?-Esparza JL, Belenguer-Varea A, Munuera CC, Gil-Guill?n V, Schwarz-Chavarri H.
Source
Centro Superior de Investigaci?n en Salud P?blica CSISP, Valencia, Spain; Centro de Salud P?blica de Castell?n, Castell?n, Spain.
Abstract
INTRODUCTION:
We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season.
METHODS:
We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100?(1-adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations.
RESULTS:
Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted IVE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those ≥60 years of age, and, 54% (4-79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization.
CONCLUSION:
Influenza vaccination was associated with significant reduction on the risk of confirmed influenza-associated hospitalization, irrespective of age and high-risk conditions.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22819720
[PubMed - as supplied by publisher]
Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study.
Puig-Barber? J, D?ez-Domingo J, Arnedo-Pena A, Ruiz-Garc?a M, P?rez-Vilar S, Mic?-Esparza JL, Belenguer-Varea A, Munuera CC, Gil-Guill?n V, Schwarz-Chavarri H.
Source
Centro Superior de Investigaci?n en Salud P?blica CSISP, Valencia, Spain; Centro de Salud P?blica de Castell?n, Castell?n, Spain.
Abstract
INTRODUCTION:
We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season.
METHODS:
We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100?(1-adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations.
RESULTS:
Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted IVE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those ≥60 years of age, and, 54% (4-79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization.
CONCLUSION:
Influenza vaccination was associated with significant reduction on the risk of confirmed influenza-associated hospitalization, irrespective of age and high-risk conditions.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22819720
[PubMed - as supplied by publisher]
