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J Virol. 2012 May 2. [Epub ahead of print]
Seasonal Trivalent Inactivated Influenza Vaccine Protects against 1918 Spanish Influenza Virus in Ferrets.
Pearce MB, Belser JA, Gustin KM, Pappas C, Houser KV, Sun X, Maines TR, Pantin-Jackwood MJ, Katz JM, Tumpey TM.
Source
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Abstract
The influenza H1N1 pandemic of 1918 was one of the worst medical catastrophes in human history. Recent studies have demonstrated that the hemagglutinin (HA) protein of the 1918 virus and 2009 H1N1 pandemic virus [A(H1N1)pdm09], the latter now a component of the seasonal trivalent inactivated influenza vaccine (TIV), share cross-reactive antigenic determinants. In this study, we demonstrate that immunization with the 2010-11 seasonal TIV induces neutralizing antibodies that cross-react with the reconstructed 1918 pandemic virus in ferrets. TIV-immunized ferrets subsequently challenged with the 1918 virus displayed a significant reduction in fever, weight loss and virus shedding compared to non-immune control ferrets. Seasonal TIV was also effective in protecting against lung infection and severe lung pathology associated with 1918 virus infection. Our data demonstrate that prior immunization with contemporary TIV provides cross-protection against the 1918 virus in ferrets. These findings suggest that exposure to A(H1N1)pdm09 through immunization, may provide protection against the reconstructed 1918 virus which as a select agent is considered to pose both biosafety and biosecurity threats.
PMID:
22553323
[PubMed - as supplied by publisher]
Seasonal Trivalent Inactivated Influenza Vaccine Protects against 1918 Spanish Influenza Virus in Ferrets.
Pearce MB, Belser JA, Gustin KM, Pappas C, Houser KV, Sun X, Maines TR, Pantin-Jackwood MJ, Katz JM, Tumpey TM.
Source
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Abstract
The influenza H1N1 pandemic of 1918 was one of the worst medical catastrophes in human history. Recent studies have demonstrated that the hemagglutinin (HA) protein of the 1918 virus and 2009 H1N1 pandemic virus [A(H1N1)pdm09], the latter now a component of the seasonal trivalent inactivated influenza vaccine (TIV), share cross-reactive antigenic determinants. In this study, we demonstrate that immunization with the 2010-11 seasonal TIV induces neutralizing antibodies that cross-react with the reconstructed 1918 pandemic virus in ferrets. TIV-immunized ferrets subsequently challenged with the 1918 virus displayed a significant reduction in fever, weight loss and virus shedding compared to non-immune control ferrets. Seasonal TIV was also effective in protecting against lung infection and severe lung pathology associated with 1918 virus infection. Our data demonstrate that prior immunization with contemporary TIV provides cross-protection against the 1918 virus in ferrets. These findings suggest that exposure to A(H1N1)pdm09 through immunization, may provide protection against the reconstructed 1918 virus which as a select agent is considered to pose both biosafety and biosecurity threats.
PMID:
22553323
[PubMed - as supplied by publisher]
