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doi:10.1016/j.vaccine.2011.09.002 |
Brief report
Trivalent inactivated influenza vaccine is not associated with sickle cell hospitalizations in adults from a large cohort
Simon J. Hambidgea, b, c, d, Corresponding Author Contact Information, E-mail The Corresponding Author, Colleen Rossa, David McClurea, Jason Glanza, d and The VSD team
Purchase
a Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA
b Department of Community Health Services, Denver Health, Denver, CO, USA
c Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
d Department of Epidemiology, University of Colorado School of Public Health, Aurora, CO, USA
Received 17 May 2011; revised 30 August 2011; Accepted 1 September 2011. Available online 17 September 2011.
Abstract
We evaluated the risk of hospitalization for sickle cell crisis (SCC) following influenza vaccination (trivalent inactivated vaccine, TIV) in adults with sickle cell disease. The cohort consisted of all adults aged 18 years and older who had a diagnosis of sickle cell disease in the Vaccine Safety Datalink from 1991 to 2006. The outcome measure was any hospitalization for SCC with the main exposure being influenza vaccine. We used a self controlled case series design to compare the incidence rates of hospitalization for SCC during the exposed and unexposed periods after TIV. No significant association between influenza vaccination and hospitalization for sickle cell crisis was found (IRR ratio 0.92, 95% confidence limits 0.66?1.28). These results provide evidence that the seasonal influenza vaccine is safe as recommended in adults who are at high risk for complications of influenza sequelae due to sickle cell disease.
Highlights
► Due to increased risk of complications from influenza, adults with sickle cell disease are recommended to receive annual influenza vaccine. ► There is little data on the association of influenza vaccine with sickle cell crises in this population. ► In this large, multi-site, population-based study spanning many years, there was no association of influenza vaccine with increased occurrence of sickle cell crises.
Brief report
Trivalent inactivated influenza vaccine is not associated with sickle cell hospitalizations in adults from a large cohort
Simon J. Hambidgea, b, c, d, Corresponding Author Contact Information, E-mail The Corresponding Author, Colleen Rossa, David McClurea, Jason Glanza, d and The VSD team
Purchase
a Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA
b Department of Community Health Services, Denver Health, Denver, CO, USA
c Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
d Department of Epidemiology, University of Colorado School of Public Health, Aurora, CO, USA
Received 17 May 2011; revised 30 August 2011; Accepted 1 September 2011. Available online 17 September 2011.
Abstract
We evaluated the risk of hospitalization for sickle cell crisis (SCC) following influenza vaccination (trivalent inactivated vaccine, TIV) in adults with sickle cell disease. The cohort consisted of all adults aged 18 years and older who had a diagnosis of sickle cell disease in the Vaccine Safety Datalink from 1991 to 2006. The outcome measure was any hospitalization for SCC with the main exposure being influenza vaccine. We used a self controlled case series design to compare the incidence rates of hospitalization for SCC during the exposed and unexposed periods after TIV. No significant association between influenza vaccination and hospitalization for sickle cell crisis was found (IRR ratio 0.92, 95% confidence limits 0.66?1.28). These results provide evidence that the seasonal influenza vaccine is safe as recommended in adults who are at high risk for complications of influenza sequelae due to sickle cell disease.
Highlights
► Due to increased risk of complications from influenza, adults with sickle cell disease are recommended to receive annual influenza vaccine. ► There is little data on the association of influenza vaccine with sickle cell crises in this population. ► In this large, multi-site, population-based study spanning many years, there was no association of influenza vaccine with increased occurrence of sickle cell crises.
