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Vaccine
. 2025 Sep 22:64:127761.
doi: 10.1016/j.vaccine.2025.127761. Online ahead of print. Association between maternal influenza vaccination and childhood vaccination among participants of the 2015 Pelotas (Brazil) birth cohort
Ana Lucia Sartori 1 , Romina Buffarini 2 , Andréa Dâmaso Bertoldi 2 , Mariângela Freitas da Silveira 3
Affiliations
Background: Influenza immunization during pregnancy is crucial to safeguarding maternal and fetal health, and is an established routine antenatal care practice. We aimed to identify the association of antenatal maternal influenza vaccination with childhood vaccination status at age 1 year and at 6-7 years of age in Brazil.
Methods: Prospective cohort study using data from mothers and children in the 2015 Pelotas Birth Cohort. Outcomes of interest included basic vaccination coverage at 1 year of age and DTP-poliovirus and influenza vaccination at 6-7 years of age. Influenza vaccination of women during pregnancy was the exposure variable. Poisson regression models were used to assess the relationship between maternal and child vaccination; prevalence ratios were obtained.
Results: Of the children included in the study, 77.2 % of them completed their routine vaccination schedules for the first year of life; at age 6-7 years, 59.9 % had complete DTP-poliovirus coverage and 40.7 % had received the influenza vaccine. Children whose mothers received the seasonal influenza vaccine during pregnancy were more likely to receive their basic first-year vaccines and the DTP-poliovirus and influenza vaccines at age 6-7 years.
Conclusions: Antenatal maternal influenza vaccination was associated with subsequent child vaccination.
Keywords: Influenza vaccines; Pediatrics; Pregnancy; Vaccination, cohort studies.
. 2025 Sep 22:64:127761.
doi: 10.1016/j.vaccine.2025.127761. Online ahead of print. Association between maternal influenza vaccination and childhood vaccination among participants of the 2015 Pelotas (Brazil) birth cohort
Ana Lucia Sartori 1 , Romina Buffarini 2 , Andréa Dâmaso Bertoldi 2 , Mariângela Freitas da Silveira 3
Affiliations
- PMID: 40987000
- DOI: 10.1016/j.vaccine.2025.127761
Background: Influenza immunization during pregnancy is crucial to safeguarding maternal and fetal health, and is an established routine antenatal care practice. We aimed to identify the association of antenatal maternal influenza vaccination with childhood vaccination status at age 1 year and at 6-7 years of age in Brazil.
Methods: Prospective cohort study using data from mothers and children in the 2015 Pelotas Birth Cohort. Outcomes of interest included basic vaccination coverage at 1 year of age and DTP-poliovirus and influenza vaccination at 6-7 years of age. Influenza vaccination of women during pregnancy was the exposure variable. Poisson regression models were used to assess the relationship between maternal and child vaccination; prevalence ratios were obtained.
Results: Of the children included in the study, 77.2 % of them completed their routine vaccination schedules for the first year of life; at age 6-7 years, 59.9 % had complete DTP-poliovirus coverage and 40.7 % had received the influenza vaccine. Children whose mothers received the seasonal influenza vaccine during pregnancy were more likely to receive their basic first-year vaccines and the DTP-poliovirus and influenza vaccines at age 6-7 years.
Conclusions: Antenatal maternal influenza vaccination was associated with subsequent child vaccination.
Keywords: Influenza vaccines; Pediatrics; Pregnancy; Vaccination, cohort studies.