Announcement

Collapse
No announcement yet.

Infect Drug Resist . Safety and Efficacy of COVID-19 Vaccine in Africa: Systematic Review

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Infect Drug Resist . Safety and Efficacy of COVID-19 Vaccine in Africa: Systematic Review

    Infect Drug Resist


    . 2023 May 18;16:3085-3100.
    doi: 10.2147/IDR.S401074. eCollection 2023. Safety and Efficacy of COVID-19 Vaccine in Africa: Systematic Review

    Selamawit Mengstu 1 , Alemseged Beyene Berha 1



    AffiliationsAbstract

    Background: Coronavirus disease 2019 (COVID-19) pandemic scared the whole world at the end of 2019, which is a communicable respiratory disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In South Africa and other African countries, the COVID-19 vaccines were subsequently approved for emergency use by the respective national regulatory authorities. There is a paucity of aggregated data that revealed the safety and efficacy of COVID-19 vaccines in Africa.
    Objective: The aim of this systematic review was to synthesize the literature on the safety and efficacy of the COVID-19 vaccine which was given in Africa.
    Methods: A systematic search was conducted on Science Direct, PubMed, EMBASE, Google Scholar, CINAHL, Cochrane Library, and direct Google searches. Only studies written in English and published articles from 2019 to October 30, 2022, which comprise nine randomized clinical trials (RCT), and four different studies including a single-arm implementation trials, prospective study, retrospective cohort study, and test-negative designs were included.
    Results: A total of 13 studies were included which contain 810,466 participants from Africa. Of these, 62.18% of the participants were female. The efficacy of COVID-19 vaccine in Africa ranges from 41.7% to 100%. Moreover, vaccine efficacy against COVID-19 variants ranges from -5.7% to 100%. In general, systemic and local adverse events following vaccination in most trials were reported with a similar pattern between the placebo and vaccine groups. Out of the total reported adverse events, most of them were mild to moderate, whereas a few were serious.
    Conclusion: Almost all current COVID-19 vaccines appear to be safe for African study participants. Regarding efficacy, the protein subunit vaccine and mRNA vaccine exhibited high efficacy (100%) in this group of participants. However, Ad26. COV2.S and ChAdOx1 nCoV-19 COVID-19 vaccines are not effective against the delta variant and B.1.351 variant, respectively.

    Keywords: Africa; COVID-19 vaccine; efficacy; immunogenicity; safety.

    ‚Äč
Working...
X