Clin Infect Dis . Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients

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Clin Infect Dis


. 2022 Aug 12;ciac652.
doi: 10.1093/cid/ciac652. Online ahead of print.
Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients


Andrew H Karaba ¹ , Weiqiang Zhou ² , Shuai Li ² , Tihitina Y Aytenfisu ¹ , Trevor S Johnston ¹ , Olivia Akinde ³ , Yolanda Eby ³ , Aura T Abedon ⁴ , Jennifer L Alejo ⁴ , Caroline X Qin ⁴ , Elizabeth A Thompson ¹ , Jacqueline M Garonzik-Wang ⁵ , Joel N Blankson ¹ , Andrea L Cox ^{1 6 7} , Justin R Bailey ¹ , Sabra L Klein ⁶ , Andrew Pekosz ⁶ , Dorry L Segev ^{4 8} , Aaron A R Tobian ³ , William A Werbel ¹



Affiliations

• PMID: 35959783
• DOI: 10.1093/cid/ciac652

Abstract

Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.

Keywords: COVID-19; Immunocompromised Hosts; SARS-CoV-2; Vaccines.