Clin Infect Dis
. 2022 Aug 12;ciac652.
doi: 10.1093/cid/ciac652. Online ahead of print.
Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients
Andrew H Karaba 1 , Weiqiang Zhou 2 , Shuai Li 2 , Tihitina Y Aytenfisu 1 , Trevor S Johnston 1 , Olivia Akinde 3 , Yolanda Eby 3 , Aura T Abedon 4 , Jennifer L Alejo 4 , Caroline X Qin 4 , Elizabeth A Thompson 1 , Jacqueline M Garonzik-Wang 5 , Joel N Blankson 1 , Andrea L Cox 1 6 7 , Justin R Bailey 1 , Sabra L Klein 6 , Andrew Pekosz 6 , Dorry L Segev 4 8 , Aaron A R Tobian 3 , William A Werbel 1
Affiliations
- PMID: 35959783
- DOI: 10.1093/cid/ciac652
Abstract
Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.
Keywords: COVID-19; Immunocompromised Hosts; SARS-CoV-2; Vaccines.