Published: 09 October 2021

The Journal of Infectious Diseases, jiab514,

Roger Y Dodd, PhD, Edward P Notari, MPH, Jaye P Brodsky, BS, Gregory A Foster, BA, Meng Xu, MPH, Paula Saá, PhD, Susan L Stramer, MS, PhD


From December 2020 to June 2021, 1,654,487 blood donors were tested for antibodies to SARS-CoV-2 S1 protein and 1,028,547 (62.17%) were reactive. A rapid increase in prevalence was due to vaccination. Among a subset of 1,567,446 donors, 729,771 (46.56%) reported SARS-CoV-2 vaccination, of whom 633,769 (86.84%) were S1-antibody reactive only, in response to vaccination and 68,269 (9.35%) were reactive to both S1 and nucleocapsid, in response to prior infection; the remainder were not reactive to either antibody. Among the 837,675 (53.44%) donors who did not report vaccination, 210,022 (25.07%) had reactivity to both antibodies and 29,446 (3.52%) to S1 only.

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