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Transpl Infect Dis
. 2021 Jul 29.
doi: 10.1111/tid.13705. Online ahead of print.
Clinical Effectiveness of COVID-19 Vaccination in Solid Organ Transplant Recipients
Saima Aslam 1 , Eric Adler 2 , Kristin Mekeel 3 , Susan J Little 1
Affiliations
- PMID: 34324256
- DOI: 10.1111/tid.13705
Abstract
Goal: We aimed to assess the incidence rate of coronavirus disease 2019 (COVID-19) in vaccinated vs. unvaccinated solid organ transplant recipients (SOTR) at our center.
Methods: We abstracted the following clinical data from our transplant registry from 1/1/2021-6/2/2021: demographics, details of COVID-19 vaccination, incidence of COVID-19, and related mortality. We calculated incidence of symptomatic COVID-19 per 1000/person days at risk and incidence rate ratio.
Results: Among 2151 SOTRs, 912 were fully vaccinated and 1239 were controls (1151 unvaccinated, 88 partially vaccinated). Almost 70% of vaccinated subjects received the mRNA-1273 vaccine. There were 65 cases of COVID-19 that occurred during the study period - 4 occurred among fully vaccinated individuals and 61 among controls (including 2 in partially vaccinated individuals). Incidence rate for COVID-19 was 0.065 (95% CI 0.024-0.17) per 1000 person days in vaccinated vs. 0.34 (95% CI 0.26-0.44) per 1000 person days in the control group; incidence rate ratio (IRR) was 0.19 (95% CI 0.049 -0.503, p<0.005). There were no COVID-19 related deaths in the 4 breakthrough infections and 2/61 (3.3%) among controls.
Conclusion: We demonstrate real world clinical effectiveness of COVID-19 vaccination in SOTRs with an almost 80% reduction in the incidence of symptomatic COVID-19 vs. unvaccinated SOTRs during the same time. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; Solid organ transplant; vaccine.