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Virology
. 2024 Jun 19:597:110149.
doi: 10.1016/j.virol.2024.110149. Online ahead of print. Peptide S4 is an entry inhibitor of SARS-CoV-2 infection
Zhiyu Liang 1 , Jiamei Wang 2 , Huan Zhang 3 , Lixia Gao 2 , Jun Xu 4 , Peiran Li 2 , Jie Yang 2 , Xinting Fu 2 , Han Duan 2 , Jiayan Liu 5 , Tiancai Liu 6 , Weifeng Ma 7 , Kun Wu 8
Affiliations
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant socioeconomic burden, and combating COVID-19 is imperative. Blocking the SARS-CoV-2 RBD-ACE2 interaction is a promising therapeutic approach for viral infections, as SARS-CoV-2 binds to the ACE2 receptors of host cells via the RBD of spike proteins to infiltrate these cells. We used computer-aided drug design technology and cellular experiments to screen for peptide S4 with high affinity and specificity for the human ACE2 receptor through structural analysis of SARS-CoV-2 and ACE2 interactions. Cellular experiments revealed that peptide S4 effectively inhibited SARS-CoV-2 and HCoV-NL63 viruses from infecting host cells and was safe for cells at effective concentrations. Based on these findings, peptide S4 may be a potential pharmaceutical agent for clinical application in the treatment of the ongoing SARS-CoV-2 pandemic.
Keywords: Angiotensin-converting enzyme 2; Entry inhibitor; S protein; SARS-CoV-2.
. 2024 Jun 19:597:110149.
doi: 10.1016/j.virol.2024.110149. Online ahead of print. Peptide S4 is an entry inhibitor of SARS-CoV-2 infection
Zhiyu Liang 1 , Jiamei Wang 2 , Huan Zhang 3 , Lixia Gao 2 , Jun Xu 4 , Peiran Li 2 , Jie Yang 2 , Xinting Fu 2 , Han Duan 2 , Jiayan Liu 5 , Tiancai Liu 6 , Weifeng Ma 7 , Kun Wu 8
Affiliations
- PMID: 38917689
- DOI: 10.1016/j.virol.2024.110149
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant socioeconomic burden, and combating COVID-19 is imperative. Blocking the SARS-CoV-2 RBD-ACE2 interaction is a promising therapeutic approach for viral infections, as SARS-CoV-2 binds to the ACE2 receptors of host cells via the RBD of spike proteins to infiltrate these cells. We used computer-aided drug design technology and cellular experiments to screen for peptide S4 with high affinity and specificity for the human ACE2 receptor through structural analysis of SARS-CoV-2 and ACE2 interactions. Cellular experiments revealed that peptide S4 effectively inhibited SARS-CoV-2 and HCoV-NL63 viruses from infecting host cells and was safe for cells at effective concentrations. Based on these findings, peptide S4 may be a potential pharmaceutical agent for clinical application in the treatment of the ongoing SARS-CoV-2 pandemic.
Keywords: Angiotensin-converting enzyme 2; Entry inhibitor; S protein; SARS-CoV-2.