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Open Forum Infect Dis
. 2024 Feb 13;11(2):ofad625.
doi: 10.1093/ofid/ofad625. eCollection 2024 Feb. Association of Nirmatrelvir/Ritonavir Treatment and COVID-19-Neutralizing Antibody Titers in a Longitudinal Health Care Worker Cohort
Slade Decker 1 , Shaoming Xiao 1 , Carly Dillen 2 , Christina M Schumacher 1 , Aaron M Milstone 1 3 , Matthew Frieman 2 , Amanda K Debes 3
Affiliations
Nirmatrelvir/ritonavir (NMV/r) is used for the treatment of coronavirus disease 2019 (COVID-19) infection. However, rebound COVID-19 infections can occur after taking NMV/r. We examined neutralizing antibodies to the severe acute respiratory syndrome coronavirus 2 spike protein before and after infection in people who did and did not take NMV/r to determine if NMV/r impedes the humoral immune response.
Keywords: COVID-19; NMV/r; antibodies; antivirals; humoral immune response; immunology; longitudinal cohort.
. 2024 Feb 13;11(2):ofad625.
doi: 10.1093/ofid/ofad625. eCollection 2024 Feb. Association of Nirmatrelvir/Ritonavir Treatment and COVID-19-Neutralizing Antibody Titers in a Longitudinal Health Care Worker Cohort
Slade Decker 1 , Shaoming Xiao 1 , Carly Dillen 2 , Christina M Schumacher 1 , Aaron M Milstone 1 3 , Matthew Frieman 2 , Amanda K Debes 3
Affiliations
- PMID: 38352152
- PMCID: PMC10863641
- DOI: 10.1093/ofid/ofad625
Nirmatrelvir/ritonavir (NMV/r) is used for the treatment of coronavirus disease 2019 (COVID-19) infection. However, rebound COVID-19 infections can occur after taking NMV/r. We examined neutralizing antibodies to the severe acute respiratory syndrome coronavirus 2 spike protein before and after infection in people who did and did not take NMV/r to determine if NMV/r impedes the humoral immune response.
Keywords: COVID-19; NMV/r; antibodies; antivirals; humoral immune response; immunology; longitudinal cohort.