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Antiviral Res
. 2024 Jan 31:105820.
doi: 10.1016/j.antiviral.2024.105820. Online ahead of print. Therapeutic antibodies and alternative formats against SARS-CoV-2
Rahel R Winiger 1 , Laurent Perez 2
Affiliations
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) heavily burdened the entire world. Despite a prompt generation of vaccines and therapeutics to confront infection, the virus remains a threat. The ancestor viral strain has evolved into several variants of concern, with the Omicron variant now having many distinct sublineages. Consequently, most available antibodies targeting the spike went obsolete and thus new therapies or therapeutic formats are needed. In this review we focus on antibody targets, provide an overview of the therapeutic progress made so far, describe novel formats being explored, and lessons learned from therapeutic antibodies that can enhance pandemic preparedness.
Keywords: Antibody; Nanobodies; RBD; SARS-CoV-2; Spike; Viral neutralization.
. 2024 Jan 31:105820.
doi: 10.1016/j.antiviral.2024.105820. Online ahead of print. Therapeutic antibodies and alternative formats against SARS-CoV-2
Rahel R Winiger 1 , Laurent Perez 2
Affiliations
- PMID: 38307147
- DOI: 10.1016/j.antiviral.2024.105820
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) heavily burdened the entire world. Despite a prompt generation of vaccines and therapeutics to confront infection, the virus remains a threat. The ancestor viral strain has evolved into several variants of concern, with the Omicron variant now having many distinct sublineages. Consequently, most available antibodies targeting the spike went obsolete and thus new therapies or therapeutic formats are needed. In this review we focus on antibody targets, provide an overview of the therapeutic progress made so far, describe novel formats being explored, and lessons learned from therapeutic antibodies that can enhance pandemic preparedness.
Keywords: Antibody; Nanobodies; RBD; SARS-CoV-2; Spike; Viral neutralization.