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J Am Chem Soc
. 2023 Dec 8.
doi: 10.1021/jacs.3c12678. Online ahead of print. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells
Xiaohong Sang 1 , Juan Wang 2 , Jiao Zhou 1 , Yan Xu 1 , Jing An 3 , Arieh Warshel 4 , Ziwei Huang 1 2 3
Affiliations
SARS-CoV-2 is the virus that causes the global pandemic of COVID-19. The main protease (Mpro) of SARS-CoV-2 is essential for viral infection and is one of the major therapeutic targets for COVID-19. Here, we report the design, synthesis, and biological characterization of a novel heterobifunctional small molecule that could effectively induce the degradation of SARS-CoV-2 Mpro and its drug-resistant mutants in HEK 293T cells, thus demonstrating a new alternative strategy for intervening with proteins important for this novel coronavirus.
. 2023 Dec 8.
doi: 10.1021/jacs.3c12678. Online ahead of print. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells
Xiaohong Sang 1 , Juan Wang 2 , Jiao Zhou 1 , Yan Xu 1 , Jing An 3 , Arieh Warshel 4 , Ziwei Huang 1 2 3
Affiliations
- PMID: 38064654
- DOI: 10.1021/jacs.3c12678
SARS-CoV-2 is the virus that causes the global pandemic of COVID-19. The main protease (Mpro) of SARS-CoV-2 is essential for viral infection and is one of the major therapeutic targets for COVID-19. Here, we report the design, synthesis, and biological characterization of a novel heterobifunctional small molecule that could effectively induce the degradation of SARS-CoV-2 Mpro and its drug-resistant mutants in HEK 293T cells, thus demonstrating a new alternative strategy for intervening with proteins important for this novel coronavirus.