Intensive Care Med
. 2023 Aug 24.
doi: 10.1007/s00134-023-07180-y. Online ahead of print. Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study
Pierre-Louis Declercq 1 , Isabelle Fournel 2 3 , Matthieu Demeyere 4 , Anissa Berraies 5 , Eléa Ksiazek 2 3 , Martine Nyunga 6 , Cédric Daubin 7 , Alexandre Ampere 8 , Bertrand Sauneuf 9 , Julio Badie 10 , Agathe Delbove 11 , Saad Nseir 12 13 , Elise Artaud-Macari 14 , Vanessa Bironneau 15 16 , Michel Ramakers 17 , Julien Maizel 18 , Arnaud-Felix Miailhe 19 , Béatrice Lacombe 20 , Nicolas Delberghe 21 , Walid Oulehri 22 , Hugues Georges 23 , Xavier Tchenio 24 , Caroline Clarot 25 , Elise Redureau 26 , Gaël Bourdin 27 , Laura Federici 28 , Mélanie Adda 29 , David Schnell 30 , Mehdi Bousta 31 , Charlotte Salmon-Gandonnière 32 , Thierry Vanderlinden 33 , Gaëtan Plantefeve 34 , David Delacour 35 , Cyrille Delpierre 36 , Gurvan Le Bouar 37 , Nicholas Sedillot 24 , Gaëtan Beduneau 38 , Antoine Rivière 39 , Nicolas Meunier-Beillard 2 3 , Stéphanie Gélinotte 1 , Jean-Philippe Rigaud 1 40 , Marie Labruyère 41 42 43 , Marjolaine Georges 44 , Christine Binquet 2 3 , Jean-Pierre Quenot 45 46 47 ; RECOVIDS trial investigators, the CRICS-TRIGGERSEP, BOREAL research networks
Collaborators, Affiliations
Purpose: Survivors after acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) are at high risk of developing respiratory sequelae and functional impairment. The healthcare crisis caused by the pandemic hit socially disadvantaged populations. We aimed to evaluate the influence of socio-economic status on respiratory sequelae after COVID-19 ARDS.
Methods: We carried out a prospective multicenter study in 30 French intensive care units (ICUs), where ARDS survivors were pre-enrolled if they fulfilled the Berlin ARDS criteria. For patients receiving high flow oxygen therapy, a flow ≥ 50 l/min and an FiO2 ≥ 50% were required for enrollment. Socio-economic deprivation was defined by an EPICES (Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé - Evaluation of Deprivation and Inequalities in Health Examination Centres) score ≥ 30.17 and patients were included if they performed the 6-month evaluation. The primary outcome was respiratory sequelae 6 months after ICU discharge, defined by at least one of the following criteria: forced vital capacity < 80% of theoretical value, diffusing capacity of the lung for carbon monoxide < 80% of theoretical value, oxygen desaturation during a 6-min walk test and fibrotic-like findings on chest computed tomography.
Results: Among 401 analyzable patients, 160 (40%) were socio-economically deprived and 241 (60%) non-deprived; 319 (80%) patients had respiratory sequelae 6 months after ICU discharge (81% vs 78%, deprived vs non-deprived, respectively). No significant effect of socio-economic status was identified on lung sequelae (odds ratio (OR), 1.19 [95% confidence interval (CI), 0.72-1.97]), even after adjustment for age, sex, most invasive respiratory support, obesity, most severe P/F ratio (adjusted OR, 1.02 [95% CI 0.57-1.83]).
Conclusions: In COVID-19 ARDS survivors, socio-economic status had no significant influence on respiratory sequelae 6 months after ICU discharge.
Keywords: ARDS; COVID-19; Deprivation; Respiratory sequelae; Socio-economic.
. 2023 Aug 24.
doi: 10.1007/s00134-023-07180-y. Online ahead of print. Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study
Pierre-Louis Declercq 1 , Isabelle Fournel 2 3 , Matthieu Demeyere 4 , Anissa Berraies 5 , Eléa Ksiazek 2 3 , Martine Nyunga 6 , Cédric Daubin 7 , Alexandre Ampere 8 , Bertrand Sauneuf 9 , Julio Badie 10 , Agathe Delbove 11 , Saad Nseir 12 13 , Elise Artaud-Macari 14 , Vanessa Bironneau 15 16 , Michel Ramakers 17 , Julien Maizel 18 , Arnaud-Felix Miailhe 19 , Béatrice Lacombe 20 , Nicolas Delberghe 21 , Walid Oulehri 22 , Hugues Georges 23 , Xavier Tchenio 24 , Caroline Clarot 25 , Elise Redureau 26 , Gaël Bourdin 27 , Laura Federici 28 , Mélanie Adda 29 , David Schnell 30 , Mehdi Bousta 31 , Charlotte Salmon-Gandonnière 32 , Thierry Vanderlinden 33 , Gaëtan Plantefeve 34 , David Delacour 35 , Cyrille Delpierre 36 , Gurvan Le Bouar 37 , Nicholas Sedillot 24 , Gaëtan Beduneau 38 , Antoine Rivière 39 , Nicolas Meunier-Beillard 2 3 , Stéphanie Gélinotte 1 , Jean-Philippe Rigaud 1 40 , Marie Labruyère 41 42 43 , Marjolaine Georges 44 , Christine Binquet 2 3 , Jean-Pierre Quenot 45 46 47 ; RECOVIDS trial investigators, the CRICS-TRIGGERSEP, BOREAL research networks
Collaborators, Affiliations
- PMID: 37620561
- DOI: 10.1007/s00134-023-07180-y
Purpose: Survivors after acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) are at high risk of developing respiratory sequelae and functional impairment. The healthcare crisis caused by the pandemic hit socially disadvantaged populations. We aimed to evaluate the influence of socio-economic status on respiratory sequelae after COVID-19 ARDS.
Methods: We carried out a prospective multicenter study in 30 French intensive care units (ICUs), where ARDS survivors were pre-enrolled if they fulfilled the Berlin ARDS criteria. For patients receiving high flow oxygen therapy, a flow ≥ 50 l/min and an FiO2 ≥ 50% were required for enrollment. Socio-economic deprivation was defined by an EPICES (Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé - Evaluation of Deprivation and Inequalities in Health Examination Centres) score ≥ 30.17 and patients were included if they performed the 6-month evaluation. The primary outcome was respiratory sequelae 6 months after ICU discharge, defined by at least one of the following criteria: forced vital capacity < 80% of theoretical value, diffusing capacity of the lung for carbon monoxide < 80% of theoretical value, oxygen desaturation during a 6-min walk test and fibrotic-like findings on chest computed tomography.
Results: Among 401 analyzable patients, 160 (40%) were socio-economically deprived and 241 (60%) non-deprived; 319 (80%) patients had respiratory sequelae 6 months after ICU discharge (81% vs 78%, deprived vs non-deprived, respectively). No significant effect of socio-economic status was identified on lung sequelae (odds ratio (OR), 1.19 [95% confidence interval (CI), 0.72-1.97]), even after adjustment for age, sex, most invasive respiratory support, obesity, most severe P/F ratio (adjusted OR, 1.02 [95% CI 0.57-1.83]).
Conclusions: In COVID-19 ARDS survivors, socio-economic status had no significant influence on respiratory sequelae 6 months after ICU discharge.
Keywords: ARDS; COVID-19; Deprivation; Respiratory sequelae; Socio-economic.