Announcement

Collapse
No announcement yet.

Br J Pharmacol . Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Br J Pharmacol . Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2


    Br J Pharmacol


    . 2022 Nov 17.
    doi: 10.1111/bph.15987. Online ahead of print.
    Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2


    Wern Hann Ng 1 2 3 , Patrick Chun Hean Tang 1 2 3 , Suresh Mahalingam 1 2 3 , Xiang Liu 1 2 3



    Affiliations

    Abstract

    A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis-associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide, resulting in an urgent need for effective therapeutic interventions. Repurposing immunosuppressive drugs that target cytokines with immunomodulatory properties is a promising approach to counteract SARS-CoV-2-induced ARDS at the infective and post-infective stages. In this minireview, we examine drugs targeting IL-1β, IL-4/IL-13, IL-6 and TNF-α tested in COVID-19 patients.

    Keywords: COVID-19; Cytokine storm; SARS-CoV-2; immunosuppressive drugs.

Working...
X