J Med Virol . Cartography of SARS-CoV-2 variants based on the susceptibility to therapeutic monoclonal antibodies

[tetano]

J Med Virol


. 2022 Nov 3.
doi: 10.1002/jmv.28275. Online ahead of print.
Cartography of SARS-CoV-2 variants based on the susceptibility to therapeutic monoclonal antibodies


Yuki Furuse ^{1 2 3 4}



Affiliations

• PMID: 36326059
• DOI: 10.1002/jmv.28275

Abstract

A comprehensive picture of a phenotypic relationship among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has been poorly studied. Here, this study presents cartography showing how the wild-type strain of SARS-CoV-2 and 14 variants are alike or different from the perspective of the susceptibility to 12 therapeutic monoclonal antibodies. The Alpha variant is close to the wild-type strain, whereas the Beta, Gamma, and Delta variants diverge from the wild type. The map highlights the very unique property of the Omicron variant. Interestingly, sublineages of the Omicron variants, BA.1, BA.2, and BA.4/5, differ substantially in the cartography. This article is protected by copyright. All rights reserved.

Keywords: COVID-19; SARS-CoV-2; antibody; evolution; neutralization; variant.