Clin Infect Dis . Remdesivir resistance in transplant recipients with persistent COVID-19

[tetano]

Clin Infect Dis


. 2022 Sep 26;ciac769.
doi: 10.1093/cid/ciac769. Online ahead of print.
Remdesivir resistance in transplant recipients with persistent COVID-19


John I Hogan ¹ , Ralf Duerr ² , Dacia Dimartino ³ , Christian Marier ³ , Sarah E Hochman ⁴ , Sapna Mehta ⁴ , Guiqing Wang ⁵ , Adriana Heguy ⁵



Affiliations

• PMID: 36156117
• DOI: 10.1093/cid/ciac769

Abstract

New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.

Keywords: Antiviral Resistance; Immunocompromise; Remdesivir; Rituximab; Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2); Solid Organ Transplant.