Glob Health Med . A novel anticoagulation treatment protocol using unfractionated heparin for coronavirus disease 2019 patients in Japan, 2022

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Glob Health Med


. 2022 Aug 31;4(4):233-236.
doi: 10.35772/ghm.2022.01030.
A novel anticoagulation treatment protocol using unfractionated heparin for coronavirus disease 2019 patients in Japan, 2022


Lubna Sato ^{1 2} , Masahiro Ishikane ¹ , Nobumasa Okumura ¹ , Noriko Iwamoto ¹ , Kayoko Hayakawa ¹ , Ken Iseki ² , Hisao Hara ³ , Norio Ohmagari ¹



Affiliations

• PMID: 36119785
• PMCID: PMC9420327
• DOI: 10.35772/ghm.2022.01030

Abstract

Hypercoagulability, which can be induced by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays an important role in the pathogenesis of coronavirus disease 2019 (COVID-19). Although anticoagulation therapy is expected to decrease the incidence of thrombosis and mortality in COVID-19 patients, the optimal use of anticoagulation therapy has not been established, especially using unfractionated heparin (UFH). Herein, we suggest a new anticoagulation treatment protocol for the use of UFH in Japanese COVID-19 patients. This protocol considers the safety regarding UFH usage, to lower major bleeding events, and reflects the latest evidence and the current situation regarding anticoagulation therapy in Japan.

Keywords: SARS-CoV-2; hypercoagulability; thrombosis.