Announcement

Collapse
No announcement yet.

Mayo Clin Proc . Curbing the Delta Surge: Clinical Outcomes After Treatment With Bamlanivimab-Etesevimab, Casirivimab-Imdevimab, or Sotrovimab for Mild to Moderate Coronavirus Disease 2019

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Mayo Clin Proc . Curbing the Delta Surge: Clinical Outcomes After Treatment With Bamlanivimab-Etesevimab, Casirivimab-Imdevimab, or Sotrovimab for Mild to Moderate Coronavirus Disease 2019


    Mayo Clin Proc


    . 2022 Sep;97(9):1641-1648.
    doi: 10.1016/j.mayocp.2022.06.015. Epub 2022 Jun 23.
    Curbing the Delta Surge: Clinical Outcomes After Treatment With Bamlanivimab-Etesevimab, Casirivimab-Imdevimab, or Sotrovimab for Mild to Moderate Coronavirus Disease 2019


    Raymund R Razonable 1 , John C O'Horo 2 , Douglas W Challener 2 , Lori Arndt 2 , Richard F Arndt 2 , Caroline G Clune 2 , Tracy L Culbertson 2 , Scott T Hall 2 , Alexander Heyliger 2 , Tammy A Jackson 2 , Brian D Kennedy 2 , Jennifer Larsen 2 , Sara N Hanson 2 , Perry W Sweeten 2 , Sidna M Tulledge-Scheitel 2 , Ravindra Ganesh 2



    Affiliations

    Abstract

    Objective: To describe and compare the clinical outcomes of bamlanivimab-etesevimab, casirivimab-imdevimab, and sotrovimab treatment of mild to moderate coronavirus disease 2019 (COVID-19) during the severe acute respiratory coronavirus 2 (SARS-CoV-2) B.1.617.2 Delta surge.
    Methods: This is a retrospective study of high-risk patients who received bamlanivimab-etesevimab, casirivimab-imdevimab, and sotrovimab for mild to moderate COVID-19 between August 1, 2021, and December 1, 2021. Rates of severe disease, hospitalization, intensive care unit admission, and death were assessed.
    Results: Among 10,775 high-risk patients who received bamlanivimab-etesevimab, casirivimab-imdevimab, or sotrovimab for mild to moderate COVID-19 during the Delta surge, 287 patients (2.7%) developed severe disease that led to hospitalization, oxygen supplementation, or death within 30 days after treatment. The rates of severe disease were low among patients treated with bamlanivimab-etesevimab (1.2%), casirivimab-imdevimab (2.9%), and sotrovimab (1.6%; P<.01). The higher rate of severe outcomes among patients treated with casirivimab-imdevimab may be related to a significantly lower COVID-19 vaccination rate in that cohort. Intensive care unit admission was comparable among patients treated bamlanivimab-etesevimab, casirivimab-imdevimab, or sotrovimab (1.0%, 1.0%, and 0.4%, respectively).
    Conclusion: This real-world study of a large cohort of high-risk patients shows low rates of severe disease, hospitalization, intensive care unit admission, and mortality after treatment with bamlanivimab-etesevimab, casirivimab-imdevimab, and sotrovimab for mild to moderate COVID-19 during the SARS-CoV-2 Delta surge.


Working...
X