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Obstet Gynecol
. 2022 Jul 1;140(1):74-76.
doi: 10.1097/AOG.0000000000004826. Epub 2022 Jun 7.
Outpatient Use of Monoclonal Antibodies in Pregnant Individuals With Mild or Moderate Coronavirus Disease 2019 (COVID-19)
Joe Eid 1 , Mahmoud Abdelwahab, Hayley Williams, Joy Lehman, Carlos Malvestutto, Mark B Landon, Maged M Costantine, Kara M Rood
Affiliations
- PMID: 35849458
- DOI: 10.1097/AOG.0000000000004826
Abstract
Treatment with monoclonal antibodies has been shown to significantly reduce the risk of hospitalization and disease progression among high-risk patients with coronavirus disease 2019 (COVID-19). Pregnant individuals were excluded from the original trials. In this single-center retrospective cohort study, we evaluated whether monoclonal antibody treatment in pregnant individuals is associated with decreased risk of hospitalization. Outcomes of patients who received the treatment were compared with those who were eligible but did not receive the treatment. Analyses were stratified by vaccination status. Unvaccinated pregnant patients with mild or moderate COVID-19 who received outpatient monoclonal antibodies were less likely to be admitted to the hospital (4.2% vs 15.7%, odds ratio 0.24, 95% CI 0.07-0.74), whereas among vaccinated patients, the treatment was not associated with a lower rate of hospitalization (2.3% vs 0%, P=.99).