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Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19

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  • Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19


    Chow JH, Rahnavard A, Gomberg-Maitland M, et al. Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19. JAMA Netw Open. 2022;5(3):e223890. doi:10.1001/jamanetworkopen.2022.3890
    Key Points
    Question Is early aspirin use in hospitalized patients with moderate COVID-19 associated with lower odds of in-hospital mortality?

    Findings In a cohort study of 112 269 patients with moderate COVID-19, early aspirin use during the first day of hospitalization was associated with lower 28-day in-hospital mortality and pulmonary embolism incidence when compared with patients who did not receive early aspirin.

    Meaning This study suggests that early aspirin use may be associated with lower odds of in-hospital mortality among hospitalized patients with moderate COVID-19; these findings warrant further study in a randomized clinical trial that includes diverse patients with cardiovascular comorbidities.


    Abstract

    Importance Prior observational studies suggest that aspirin use may be associated with reduced mortality in high-risk hospitalized patients with COVID-19, but aspirin’s efficacy in patients with moderate COVID-19 is not well studied.

    Objective To assess whether early aspirin use is associated with lower odds of in-hospital mortality in patients with moderate COVID-19.



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