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J Med Virol . Effectiveness and Safety of Ivermectin in COVID-19 Patients: A Prospective Study at A Safety-Net Hospital

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  • J Med Virol . Effectiveness and Safety of Ivermectin in COVID-19 Patients: A Prospective Study at A Safety-Net Hospital


    J Med Virol


    . 2021 Nov 23.
    doi: 10.1002/jmv.27469. Online ahead of print.
    Effectiveness and Safety of Ivermectin in COVID-19 Patients: A Prospective Study at A Safety-Net Hospital


    Muhammet Ozer 1 , Suleyman Yasin Goksu 2 , Reena Conception 3 , Esad Ulker 1 , Rodolfo Magallanes Balderas 1 , Mohammed Mahdi 1 , Zulfiya Manning 1 , Kim To 3 , Muhammad Effendi 3 , Rajashree Anandakrishnan 4 , Marc Whitman 4 , Manish Gugnani 5



    Affiliations

    Abstract

    Background: Ivermectin has been found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. It is unknown whether this inhibition of SARS-CoV-2 replication correlates with improved clinical outcomes.
    Objective: To assess the effectiveness and safety of ivermectin in hospitalized patients with COVID-19.
    Methods and materials: A total of 286 patients with COVID-19 were included in the study. Univariate analysis of the primary mortality outcome and comparisons between treatment groups were determined. Logistic regression and propensity score matching (PSM) was used to adjust for confounders.
    Results: Patients in the ivermectin group received 2 doses of ivermectin at 200 μg/kg in addition to usual clinical care on hospital days 1 and 3. The ivermectin group had a significantly higher length of hospital stay than the control group; however, this significance did not maintain on multivariable logistic regression analysis. The length of ICU stay and duration of mechanical ventilation were longer in the control group. However, a mortality benefit was not seen with ivermectin treatment before and after PSM (p values = 0.07 and 0.11, respectively). Intensive care unit (ICU) admission, and intubation rate were not significantly different between the groups (p=0.49, and p=1.0, respectively).
    Conclusion: No differences were found between groups regarding the length of hospital stay, ICU admission, intubation rate, and in-hospital mortality. This article is protected by copyright. All rights reserved.



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