Announcement

Collapse
No announcement yet.

EBioMedicine . The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • EBioMedicine . The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model


    EBioMedicine


    . 2021 Sep 24;72:103595.
    doi: 10.1016/j.ebiom.2021.103595. Online ahead of print.
    The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model


    Rana Abdelnabi 1 , Caroline S Foo 1 , Suzanne J F Kaptein 1 , Xin Zhang 1 , Thuc Nguyen Dan Do 1 , Lana Langendries 1 , Laura Vangeel 1 , Judith Breuer 2 , Juanita Pang 2 , Rachel Williams 2 , Valentijn Vergote 1 , Elisabeth Heylen 1 , Pieter Leyssen 1 , Kai Dallmeier 1 , Lotte Coelmont 1 , Arnab K Chatterjee 3 , Raf Mols 4 , Patrick Augustijns 4 , Steven De Jonghe 1 , Dirk Jochmans 1 , Birgit Weynand 5 , Johan Neyts 6



    AffiliationsFree article

    Abstract

    Background: Favipiravir and Molnupiravir, orally available antivirals, have been reported to exert antiviral activity against SARS-CoV-2. First efficacy data have been recently reported in COVID-19 patients.
    Methods: We here report on the combined antiviral effect of both drugs in a SARS-CoV-2 Syrian hamster infection model. The infected hamsters were treated twice daily with the vehicle (the control group) or a suboptimal dose of each compound or a combination of both compounds.
    Findings: When animals were treated with a combination of suboptimal doses of Molnupiravir and Favipiravir at the time of infection, a marked combined potency at endpoint is observed. Infectious virus titers in the lungs of animals treated with the combination are reduced by ∼5 log10 and infectious virus are no longer detected in the lungs of >60% of treated animals. When start of treatment was delayed with one day a reduction of titers in the lungs of 2.4 log10 was achieved. Moreover, treatment of infected animals nearly completely prevented transmission to co-housed untreated sentinels. Both drugs result in an increased mutation frequency of the remaining viral RNA recovered from the lungs of treated animals. In the combo-treated hamsters, an increased frequency of C-to-T mutations in the viral RNA is observed as compared to the single treatment groups which may explain the pronounced antiviral potency of the combination.
    Interpretation: Our findings may lay the basis for the design of clinical studies to test the efficacy of the combination of Molnupiravir/Favipiravir in the treatment of COVID-19.
    Funding: stated in the acknowledgment.

    Keywords: Antivirals; Favipiravir, hamsters, coronavirus; Molnupiravir; SARS-CoV-2.

Working...
X