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J Infect Dis . Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins

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  • J Infect Dis . Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins


    J Infect Dis


    . 2021 Sep 20;jiab482.
    doi: 10.1093/infdis/jiab482. Online ahead of print.
    Plasma from post-COVID-19 and COVID-19-Vaccinated Donors Results in Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins


    Michael Karbiener 1 , Maria R Farcet 1 , Julia Schwaiger 1 , Nicholas Powers 2 , James Lenart 2 , Joseph M Stewart 2 , Hema Tallman 2 , Thomas R Kreil 1



    Affiliations

    Abstract

    From September 2020, some immunoglobulin (IG) lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. Paralleled by the increasing numbers of post-COVID-19 donors, IG lot antibody positivity increased to 93% by January 2021, at a mean titer of ~30 IU/mL. The correlation predicted anti-SARS-CoV-2 potency to reach 345 IU/mL by July 2021. In addition to post-COVID-19 donors, the rapidly increasing number of COVID-19 vaccinated plasma donors now result in a mean antibody titer of >600 IU/mL already in July 2021 IG lots, with SARS-CoV-2 antibody titers for several lots even higher than earlier produced hyperimmune globulin products.

    Keywords: COVID-19; CoVIg-19; Primary immunodeficiency; SARS coronavirus 2 antibody potency; SARS-CoV-2; Secondary immunodeficiency; hyperimmune globulin; immunoglobulin; intravenous immune globulin; neutralizing antibodies; plasma; prophylaxis.

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