J Med Virol . Investigation of plasma exchange and hemoperfusion effects and complications for the treatment of patients with severe COVID-19 (SARS-CoV-2) disease: a systematic scoping review

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J Med Virol


. 2021 Jul 6.
doi: 10.1002/jmv.27182. Online ahead of print.
Investigation of plasma exchange and hemoperfusion effects and complications for the treatment of patients with severe COVID-19 (SARS-CoV-2) disease: a systematic scoping review


Razieh Sadat Mousavi-Roknabadi ^{1 2} , Fatemeh Haddad ³ , Aylar Fazlzadeh ⁴ , Dorna Kheirabadi ⁵ , Hamidreza Dehghan ⁶ , Mohammad Rezaeisadrabadi ^{4 7}



Affiliations

• PMID: 34228355
• DOI: 10.1002/jmv.27182

Abstract

Background: Some previous studies suggested that the plasma exchange (PE) and hemoperfusion (HP) played a cardinal role in treatment of severe COVID-19 cases through diminishing the cytokine storm. This study aimed to assess the effects of PE and HP on cytokine storm in patients with severe COVID-19 through a systematic scoping review.
Methods: Four Electronic databases [Medline (accessed from PubMed), Scopus, Science Direct, and Cochrane library] were searched systematically on February 2, 2021 using MESH terms and related keywords in English language. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, their findings were assessed and reported.
Results: Total of 755 articles were obtained within the first step of searching, and 518 ones remained after removing the duplications. Through the title and abstract screening, 438 were removed. Of the rest, 59 papers were excluded. Finally, after reading the full text of the remained articles, 21 ones included in data extraction. Most of the previous reported evidence were case reports and case series. Findings were summarized in two categories; First category encompassed nine studies regarding to HP and continuous renal replacement therapy (CRRT), and second category was included twelve studies about PE.
Conclusion: The results revealed that HP and PE within the cytokine storm phase would be beneficial with high probability in the treatment of severely ill COVID-19 patients. This article is protected by copyright. All rights reserved.

Keywords: COVID-19; Coronavirus; Hemoperfusion; Plasma exchange; Plasmapheresis; Renal replacement therapy.