BMC Infect Dis . Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection

[tetano]

BMC Infect Dis


. 2021 May 18;21(1):450.
doi: 10.1186/s12879-021-06168-7.
Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection


Alireza Davoudi ¹ , Narges Najafi ¹ , Mohsen Aarabi ² , Atefeh Tayebi ¹ , Roja Nikaeen ³ , Hamideh Izadyar ¹ , Zahra Salar ⁴ , Leila Delavarian ¹ , Narges Vaseghi ⁵ , Zahra Daftarian ¹ , Fatemeh Ahangarkani ⁶



Affiliations

• PMID: 34006228
• DOI: 10.1186/s12879-021-06168-7

Abstract

Background: A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19.
Methods: In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency.
Results: One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ? 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05).
Conclusions: Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection.

Keywords: COVID-19; Coronavirus; Insufficiency; SARS-CoV-2; Sufficiency; Vitamin D.

[JJackson]

This is a preprint and I suspect the bit in red is a typo The vitamin D levels of the patients were 27.19 ? 20.17 ng/mL.
The DOI link does not work but this one does DOI: 10.21203/rs.3.rs-121748/v1
In this version the results section now reads

Results


153 patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. In total, 62.7% (n-=96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n=57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n=75) of the patients suffered from at least one underlying disease. Vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization, lung involvement, intensive care unit (ICU) admission, invasive and non-invasive ventilation, the severity of disease or death.

[Emily]

Thank you, JJackson. The typo really had me wondering.

[bertrand789]

Is this a link showing the actions taken to ensure that what should be in place with regard to the vitamin D file, such as the tetanus vaccine?

There is software for such, for, depending on his skin color, suitable for general recommendations?

[Emily]

Tetano posted a study that showed that Vit D was very important in outcomes for the black patients in the study, but was not at the level used as the study's comparator in white patients. I can't find it now but it was really important research. Ignoring this truly would be a form of institutional racism.

[Emily]

Found the study:

https://flutrackers.com/forum/forum/welcome-to-the-scientific-library/treatments/910325-jama-netw-open-association-of-vitamin-d-levels-race-ethnicity-and-clinical-characteristics-with-covid-19-test-results

[bertrand789]

@emily:
that's why some people want to read the recommendations of a competent, black-skinned person.