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BMC Infect Dis . Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial

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  • BMC Infect Dis . Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial


    BMC Infect Dis


    . 2021 Apr 10;21(1):337.
    doi: 10.1186/s12879-021-06045-3.
    Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial


    Keivan Ranjbar 1 2 , Mohsen Moghadami 3 , Alireza Mirahmadizadeh 4 5 , Mohammad Javad Fallahi 1 6 , Vahid Khaloo 7 , Reza Shahriarirad 1 2 , Amirhossein Erfani 1 2 , Zohre Khodamoradi 6 8 , Mohammad Hasan Gholampoor Saadi 2



    Affiliations

    Abstract

    Background: Although almost a year has passed since the Coronavirus disease 2019 (COVID-19) outbreak and promising reports of vaccines have been presented, we still have a long way until these measures are available for all. Furthermore, the most appropriate corticosteroid and dose in the treatment of COVID-19 have remained uncertain. We conducted a study to assess the effectiveness of methylprednisolone treatment versus dexamethasone for hospitalized COVID-19 patients.
    Methods: In this prospective triple-blinded randomized controlled trial, we enrolled 86 hospitalized COVID-19 patients from August to November 2020, in Shiraz, Iran. The patients were randomly allocated into two groups to receive either methylprednisolone (2 mg/kg/day; intervention group) or dexamethasone (6 mg/kg/day; control group). Data were assessed based on a 9-point WHO ordinal scale extending from uninfected (point 0) to death (point 8).
    Results: There were no significant differences between the groups on admission. However, the intervention group demonstrated significantly better clinical status compared to the control group at day 5 (4.02 vs. 5.21, p = 0.002) and day 10 (2.90 vs. 4.71, p = 0.001) of admission. There was also a significant difference in the overall mean score between the intervention group and the control group, (3.909 vs. 4.873 respectively, p = 0.004). The mean length of hospital stay was 7.43 ? 3.64 and 10.52 ? 5.47 days in the intervention and control groups, respectively (p = 0.015). The need for a ventilator was significantly lower in the intervention group than in the control group (18.2% vs 38.1% p = 0.040).
    Conclusion: In hospitalized hypoxic COVID-19 patients, methylprednisolone demonstrated better results compared to dexamethasone.
    Trial registration: The trial was registered with IRCT.IR (08/04/2020-No. IRCT20200204046369N1 ).

    Keywords: COVID-19; Corticosteroid; Dexamethasone; Methylprednisolone; Randomized controlled trial.

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