Dig Dis Sci . Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis

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Dig Dis Sci


. 2021 Feb 24.
doi: 10.1007/s10620-021-06872-z. Online ahead of print.
Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis


Chenyu Sun ¹ , Yue Chen ² , Lei Hu ² , Yile Wu ^{3 4} , Mingming Liang ^{3 4} , Mubashir Ayaz Ahmed ⁵ , Chandur Bhan ⁵ , Zhichun Guo ⁶ , Hongru Yang ⁶ , Yijing Zuo ⁶ , Yue Yan ⁶ , Qin Zhou ⁷



Affiliations

• PMID: 33625613
• DOI: 10.1007/s10620-021-06872-z

Abstract

Background: Famotidine was reported to potentially provide benefits to Coronavirus Disease 2019 (COVID-19) patients. However, it remains controversial whether it is effective in treating COVID-19.
Aims: This study aimed to explore whether famotidine use is associated with reduced risk of the severity, death, and intubation for COVID-19 patients.
Methods: This study was registered on International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42020213536). A comprehensive search was performed to identify relevant studies up to October 2020. I-squared statistic and Q-test were utilized to assess the heterogeneity. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated through the random effects or fixed effects model according to the heterogeneity. Subgroup analyses, sensitivity analysis, and publication bias assessment were also conducted.
Results: Five studies including 36,635 subjects were included. We found that famotidine use was associated with a statistically non-significant reduced risk of progression to severe disease, death, and intubation for Coronavirus Disease 2019 (COVID-19) patients (pooled RR was 0.82, 95% CI = 0.52-1.30, P = 0.40).
Conclusion: Famotidine has no significant protective effect in reducing the risk of developing serious illness, death, and intubation for COVID-19 patients. More original studies are needed to further clarify whether it is associated with reduced risk of the severity, death, and intubation for COVID-19 patients.

Keywords: COVID-19; Famotidine; Meta-analysis.