Gene . The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19

[tetano]

Gene


. 2021 Feb 4;145471.
doi: 10.1016/j.gene.2021.145471. Online ahead of print.
The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19


Ehsan Saburi ¹ , Mohamadfoad Abazari ² , Hadi Hasannia ³ , Reyhaneh Nassiri Mansour ⁴ , Reza Eshaghi-Gorji ⁴ , Mobina Gheibi ⁴ , Mohamad Rahmati ⁵ , Seyed Ehsan Enderami ⁶



Affiliations

• PMID: 33549712
• PMCID: PMC7860931
• DOI: 10.1016/j.gene.2021.145471

Free PMC article

Abstract

In addition to causing health concerns, the new coronavirus has been considered in the world with its unknown mechanism of physiopathogenesis and long-term effects after patient recovery. Pulmonary, renal, hepatic and cardiac complications have been reported so far. Beside the researchers' focus on finding vaccines and using conventional therapies, cell-based therapy might be an effective therapeutic strategy. The use of mesenchymal stem cells (MSCs) is one of the options due to their immunomodulatory properties and their proven effects in the treatment of many diseases. As MSCs are not infected with covid-19, there is evidence that it modulates the immune system and prevents the virus from clotting. Despite the beginning of numerous clinical trials in the use of mesenchymal stem cells, it is necessary to set a practical guideline that specifies items such as cell origin, number of cells, frequency of injection, injection site, etc.

Keywords: Covid 19; Mesenchymal stem cells; Tissue regeneration; Treatment.